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Acitretin is the drug of choice for the treatment of psoriasis, but due to its poor solubility, the development of oral and topical formulations of acitretin has been restricted. The aim of the present investigation was to enhance the solubility of acitretin. Solid dispersions of acitretin were prepared using a lipidic solubilizer, Gelucire® 44/14. These solid dispersions were characterized through FT-IR, DSC, XRD, drug content and solubility studies. The most solubilized dispersion was loaded on an N,N-methylenebisacrylamide microporous cryogel. Physical parameters of the solubilized drug such as the porosity, rheological behaviour, surface properties, appearance, drug content and diffusion behaviour were studied. It was concluded that the solubilized form of acitretin, loaded on a surface-modified cryogel, is the best option for the treatment of psoriasis. The hydration of the skin was excellent, and the permeability of the acitretin into the skin was better. [ABSTRACT FROM AUTHOR]

Drug release properties for transdermal route can be better modified as per requirement which is mostly dependent upon the carrier system. In case of organic film-forming systems, the physical properties may not be achieved for successful delivery of drug through transdermal route. A novel organic-inorganic hybrid film-forming gel may fulfil these expectations to many extend. The present study focuses on the development of the organic-inorganic hybrid film-forming gel. A smooth, transparent, clear film-forming gel of tramadol was prepared for application on the intact skin with better comfort and modified drug release rate properties. The key properties of the adhesive films produced from the hybrid gels were investigated and the results showed that the incorporation of appropriate PVA: TEOS: Glycerine: HCl in the ratio of 46:12.5:25.5:6 respectively. Resultant hybrid film-forming gel has modified the physical properties and improved drug release properties. Furthermore, the investigations of skin irritation suggested no irritation to skin after topical application. This study has provided an alternative to the presently available organic gel and films for transdermal delivery of drugs with better patient compliance and modified physical and chemical stability. [ABSTRACT FROM AUTHOR]