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Predicting diseases in the early stages is extremely important. By taking advantage of advances in deep learning and fuzzy logic techniques, a new model is proposed in this paper for disease evaluation depending on the adaptive neuro-fuzzy inference system (ANFIS) with a genetic algorithm (GA) for classification, and the pre-trained DenseNet-201 model for feature extraction, in addition to the whale optimization algorithm (WOA) for feature selection. Two medical databases (chest X-ray and MRI brain tumor) for the diagnosis of two disease types were used as input in the suggested model. The optimization of ANFIS parameters was performed by GA to achieve the optimum prediction capability. DenseNet-201 for feature extraction was employed to obtain better classification accuracy. Having more features sometimes leads to lower accuracy, and this issue can be rectified using a feature selection strategy WOA which gave good results. The proposed model was evaluated utilizing statistical metrics root mean square error (RMSE), mean square error (MSE), standard deviation (STD), and coefficient of determination ( R 2 ), and it was compared with the conventional ANFIS model, with the proposed model (ANFIS-GA) showing a superior prediction capability over the ANFIS model. As a result, it can be concluded that the proposed ANFIS-GA model is efficient and has the potential for a robust diseases evaluation with good accuracy. Also, we conclude from this work that integrating optimization algorithms with ANFIS boosts its performance, resulting in a more accurate and reliable model. [ABSTRACT FROM AUTHOR]

This paper discusses the problem of detecting cancer using such biomarkers as blood protein markers. The purpose of this research is to propose an approach for making decisions in the diagnosis of cancer through the creation of cost-sensitive SVM classifiers on the basis of datasets with a variety of features of different nature. Such datasets may include compositions of known features corresponding to blood protein markers and new features constructed using methods for calculating entropy and fractal dimensions, as well as using the UMAP algorithm. Based on these datasets, multiclass SVM classifiers were developed. They use cost-sensitive learning principles to overcome the class imbalance problem, which is typical for medical datasets. When implementing the UMAP algorithm, various variants of the loss function were considered. This was performed in order to select those that provide the formation of such new features that ultimately allow us to develop the best cost-sensitive SVM classifiers in terms of maximizing the mean value of the metric M a c r o F 1 − s c o r e . The experimental results proved the possibility of applying the UMAP algorithm, approximate entropy and, in addition, Higuchi and Katz fractal dimensions to construct new features using blood protein markers. It turned out that when working with the UMAP algorithm, the most promising is the application of a loss function on the basis of fuzzy cross-entropy, and the least promising is the application of a loss function on the basis of intuitionistic fuzzy cross-entropy. Augmentation of the original dataset with either features on the basis of the UMAP algorithm, features on the basis of the UMAP algorithm and approximate entropy, or features on the basis of approximate entropy provided the creation of the three best cost-sensitive SVM classifiers with mean values of the metric M a c r o F 1 − s c o r e increased by 5.359%, 5.245% and 4.675%, respectively, compared to the mean values of this metric in the case when only the original dataset was utilized for creating the base SVM classifier (without performing any manipulations to overcome the class imbalance problem, and also without introducing new features). [ABSTRACT FROM AUTHOR]

Intuitionistic fuzzy information is a potent tool for medical diagnosis applications as it can represent imprecise and uncertain data. However, making decisions based on this information can be challenging due to its inherent ambiguity. To overcome this, power aggregation operators can effectively combine various sources of information, including expert opinions and patient data, to arrive at a more accurate diagnosis. The timely and accurate diagnosis of medical conditions is crucial for determining the appropriate treatment plans and improving patient outcomes. In this paper, we developed a novel approach for the three-way decision model by utilizing decision-theoretic rough sets and power aggregation operators. The decision-theoretic rough set approach is essential in medical diagnosis as it can manage vague and uncertain data. The redesign of the model using interval-valued classes for intuitionistic fuzzy information further improved the accuracy of the diagnoses. The intuitionistic fuzzy power weighted average (IFPWA) and intuitionistic fuzzy power weighted geometric (IFPWG) aggregation operators are used to aggregate the attribute values of the information system. The established operators are used to combine information within the intuitionistic fuzzy information system. The outcomes of various alternatives are then transformed into interval-valued classes through discretization. Bayesian decision rules, incorporating expected loss factors, are subsequently generated based on this foundation. This approach helps in effectively combining various sources of information to arrive at more accurate diagnoses. The proposed approach is validated through a medical case study where the participants are classified into three different regions based on their symptoms. In conclusion, the decision-theoretic rough set approach, along with power aggregation operators, can effectively manage vague and uncertain information in medical diagnosis applications. The proposed approach can lead to timely and accurate diagnoses, thereby improving patient outcomes. [ABSTRACT FROM AUTHOR]

The SH-SY5Y neuroblastoma cell line is often used as an in vitro model of neuronal function and is widely applied to study the molecular events leading to Alzheimer's disease (AD). Indeed, recently, basic research on SH-SY5Y cells has provided interesting insights for the discovery of new drugs and biomarkers for improved AD treatment and diagnosis. At the same time, untargeted NMR metabolomics is widely applied to metabolic profile analysis and screening for differential metabolites, to discover new biomarkers. In this paper, a compression technique based on convolutional autoencoders is proposed, which can perform a high dimensionality reduction in the spectral signal (up to more than 300 times), maintaining informative features (guaranteed by a reconstruction error always smaller than 5%). Moreover, before compression, an ad hoc preprocessing method was devised to remedy the scarcity of available data. The compressed spectral data were then used to train some SVM classifiers to distinguish diseased from healthy cells, achieving an accuracy close to 78%, a significantly better performance with respect to using standard PCA-compressed data. [ABSTRACT FROM AUTHOR]

In recent years, deep learning has been successfully applied to medical image analysis and provided assistance to medical professionals. Machine learning is being used to offer diagnosis suggestions, identify regions of interest in images, or augment data to remove noise. Training models for such tasks require a large amount of labeled data. It is often difficult to procure such data due to the fact that these requires experts to manually label them, in addition to the privacy and legal concerns that limiting their collection. Due to this, creating self-supervision learning methods and domain-adaptation techniques dedicated to this domain is essential. This paper reviews concepts from the field of deep learning and how they have been applied to medical image analysis. We also review the current state of self-supervised learning methods and their applications to medical images. In doing so, we will also present the resource ecosystem of researchers in this field, such as datasets, evaluation methodologies, and benchmarks. [ABSTRACT FROM AUTHOR]

Pulmonary diseases are life-threatening diseases commonly observed worldwide, and timely diagnosis of these diseases is essential. Meanwhile, increased use of Convolution Neural Networks has promoted the advancement of computer-assisted clinical recommendation systems for diagnosing diseases using chest radiographs. The texture and shape of the tissues in the diagnostic images are essential aspects of prognosis. Therefore, in the latest studies, the vast set of images with a larger resolution is paired with deep learning techniques to enhance the performance of the disease diagnosis in chest radiographs. Moreover, pulmonary diseases have irregular and different sizes; therefore, several studies sought to add new components to existing deep learning techniques for acquiring multi-scale imaging features from diagnostic chest X-rays. However, most of the attempts do not consider the computation overhead and lose the spatial details in an effort to capture the larger receptive field for obtaining the discriminative features from high-resolution chest X-rays. In this paper, we propose an explainable and lightweight Multi-Scale Chest X-ray Network (MS-CheXNet) to predict abnormal diseases from the diagnostic chest X-rays. The MS-CheXNet consists of four following main subnetworks: (1) Multi-Scale Dilation Layer (MSDL), which includes multiple and stacked dilation convolution channels that consider the larger receptive field and captures the variable sizes of pulmonary diseases by obtaining more discriminative spatial features from the input chest X-rays; (2) Depthwise Separable Convolution Neural Network (DS-CNN) is used to learn imaging features by adjusting lesser parameters compared to the conventional CNN, making the overall network lightweight and computationally inexpensive, making it suitable for mobile vision tasks; (3) a fully connected Deep Neural Network module is used for predicting abnormalities from the chest X-rays; and (4) Gradient-weighted Class Activation Mapping (Grad-CAM) technique is employed to check the decision models' transparency and understand their ability to arrive at a decision by visualizing the discriminative image regions and localizing the chest diseases. The proposed work is compared with existing disease prediction models on chest X-rays and state-of-the-art deep learning strategies to assess the effectiveness of the proposed model. The proposed model is tested with a publicly available Open-I Dataset and data collected from a private hospital. After the comprehensive assessment, it is observed that the performance of the designed approach showcased a 7% to 18% increase in accuracy compared to the existing method. [ABSTRACT FROM AUTHOR]

Osteosarcoma is a malignant osteosarcoma that is extremely harmful to human health. Magnetic resonance imaging (MRI) technology is one of the commonly used methods for the imaging examination of osteosarcoma. Due to the large amount of osteosarcoma MRI image data and the complexity of detection, manual identification of osteosarcoma in MRI images is a time-consuming and labor-intensive task for doctors, and it is highly subjective, which can easily lead to missed and misdiagnosed problems. AI medical image-assisted diagnosis alleviates this problem. However, the brightness of MRI images and the multi-scale of osteosarcoma make existing studies still face great challenges in the identification of tumor boundaries. Based on this, this study proposed a prior guidance-based assisted segmentation method for MRI images of osteosarcoma, which is based on the few-shot technique for tumor segmentation and fine fitting. It not only solves the problem of multi-scale tumor localization, but also greatly improves the recognition accuracy of tumor boundaries. First, we preprocessed the MRI images using prior generation and normalization algorithms to reduce model performance degradation caused by irrelevant regions and high-level features. Then, we used a prior-guided feature abdominal muscle network to perform small-sample segmentation of tumors of different sizes based on features in the processed MRI images. Finally, using more than 80,000 MRI images from the Second Xiangya Hospital for experiments, the DOU value of the method proposed in this paper reached 0.945, which is at least 4.3% higher than other models in the experiment. We showed that our method specifically has higher prediction accuracy and lower resource consumption. [ABSTRACT FROM AUTHOR]

Data normalization is a data preprocessing task and one of the first to be performed during intellectual analysis, particularly in the case of tabular data. The importance of its implementation is determined by the need to reduce the sensitivity of the artificial intelligence model to the values of the features in the dataset to increase the studied model's adequacy. This paper focuses on the problem of effectively preprocessing data to improve the accuracy of intellectual analysis in the case of performing medical diagnostic tasks. We developed a new two-step method for data normalization of numerical medical datasets. It is based on the possibility of considering both the interdependencies between the features of each observation from the dataset and their absolute values to improve the accuracy when performing medical data mining tasks. We describe and substantiate each step of the algorithmic implementation of the method. We also visualize the results of the proposed method. The proposed method was modeled using six different machine learning methods based on decision trees when performing binary and multiclass classification tasks. We used six real-world, freely available medical datasets with different numbers of vectors, attributes, and classes to conduct experiments. A comparison between the effectiveness of the developed method and that of five existing data normalization methods was carried out. It was experimentally established that the developed method increases the accuracy of the Decision Tree and Extra Trees Classifier by 1–5% in the case of performing the binary classification task and the accuracy of the Bagging, Decision Tree, and Extra Trees Classifier by 1–6% in the case of performing the multiclass classification task. Increasing the accuracy of these classifiers only by using the new data normalization method satisfies all the prerequisites for its application in practice when performing various medical data mining tasks. [ABSTRACT FROM AUTHOR]

Today, artificial intelligence (AI) and machine learning (ML) have dramatically advanced in various industries, especially medicine. AI describes computational programs that mimic and simulate human intelligence, for example, a person's behavior in solving problems or his ability for learning. Furthermore, ML is a subset of artificial intelligence. It extracts patterns from raw data automatically. The purpose of this paper is to help researchers gain a proper understanding of machine learning and its applications in healthcare. In this paper, we first present a classification of machine learning-based schemes in healthcare. According to our proposed taxonomy, machine learning-based schemes in healthcare are categorized based on data pre-processing methods (data cleaning methods, data reduction methods), learning methods (unsupervised learning, supervised learning, semi-supervised learning, and reinforcement learning), evaluation methods (simulation-based evaluation and practical implementation-based evaluation in real environment) and applications (diagnosis, treatment). According to our proposed classification, we review some studies presented in machine learning applications for healthcare. We believe that this review paper helps researchers to familiarize themselves with the newest research on ML applications in medicine, recognize their challenges and limitations in this area, and identify future research directions. [ABSTRACT FROM AUTHOR]

The medical diagnosis of many critical diseases is difficult as it usually requires the combined effort of several doctors. At this time, the process of medical diagnosis is actually a group decision-making (GDM) problem. In group medical diagnosis, considering doctors' weight information and fusing the interaction relation of symptoms remain open issues. To address this problem, a group decision-making method for intuitionistic fuzzy soft environments is proposed for medical diagnosis because the intuitionistic fuzzy soft set (IFSS) integrates the advantages of the soft set and intuitionistic fuzzy set (IFS). Intuitionistic fuzzy soft weighted Muirhead mean operators are constructed by combining Einstein operations with the Muirhead mean (MM) operator, and some properties and results are revealed. A group medical diagnosis model with unknown doctor weight information and incomplete intuitionistic fuzzy soft information is proposed. Similarity measures of the intuitionistic fuzzy soft matrix (IFSM) given by the doctors are used to estimate the incomplete information. To take into account the advantages of objective weight and subjective weight, the combined weights of doctors are calculated based on the IFSMs' similarity measure and doctors' grades. The developed operators are then used to combine the evaluation information and handle the correlation of input arguments in the group medical diagnosis process. Finally, a numerical problem is selected to illustrate the superiority of the proposed approach compared to related methods. The combined weights are determined to overcome the shortcomings of the single-weight method to some extent. Meanwhile, the proposed method is more comprehensive, and can provide more flexible and reasonable choices for group medical diagnosis problems. [ABSTRACT FROM AUTHOR]

Autism Spectrum Disorder (ASD) presents significant diagnostic challenges due to its complex, heterogeneous nature. This study explores a novel approach to enhance the accuracy and reliability of ASD diagnosis by integrating resting-state functional magnetic resonance imaging with demographic data (age, gender, and IQ). This study is based on improving the spectral graph convolutional neural network (GCN). It introduces a multi-view attention fusion module to extract useful information from different views. The graph's edges are informed by demographic data, wherein an edge-building network computes weights grounded in demographic information, thereby bolstering inter-subject correlation. To tackle the challenges of oversmoothing and neighborhood explosion inherent in deep GCNs, this study introduces DropEdge regularization and residual connections, thus augmenting feature diversity and model generalization. The proposed method is trained and evaluated on the ABIDE-I and ABIDE-II datasets. The experimental results underscore the potential of integrating multi-view and multimodal data to advance the diagnostic capabilities of GCNs for ASD. [ABSTRACT FROM AUTHOR]

In this paper, we propose and analyze a mathematical model for the dynamics of visceral leishmaniasis with seasonality. Our results show that the disease-free equilibrium is globally asymptotically stable under certain conditions when R0, the basic reproduction number, is less than unity. When R0 > 1 and under some conditions, then our system has a unique positive ω-periodic solution that is globally asymptotically stable. Applying two controls, vaccination and treatment, to our model forces the system to be non-periodic, and all fractions of infected populations settle on a very low level. [ABSTRACT FROM AUTHOR]

In the dynamic landscape of healthcare, decision support systems (DSS) confront continuous challenges, especially in the era of big data. Background: This study extends a Q&A-based medical DSS framework that utilizes semantic technologies for disease inference based on a patient's symptoms. The framework inputs "evidential symptoms" (symptoms experienced by the patient) and outputs a ranked list of hypotheses, comprising an ordered pair of a disease and a characteristic symptom. Our focus is on advancing the framework by introducing ontology integration to semantically enrich its knowledgebase and refine its outcomes, offering three key advantages: Propagation, Hierarchy, and Range Expansion of symptoms. Additionally, we assessed the performance of the fully implemented framework in Python. During the evaluation, we inspected the framework's ability to infer the patient's disease from a subset of reported symptoms and evaluated its effectiveness in ranking it prominently among hypothesized diseases. Methods: We conducted the expansion using dedicated algorithms. For the evaluation process, we defined various metrics and applied them across our knowledge base, encompassing 410 patient records and 41 different diseases. Results: We presented the outcomes of the expansion on a toy problem, highlighting the three expansion advantages. Furthermore, the evaluation process yielded promising results: With a third of patient symptoms as evidence, the framework successfully identified the disease in 94% of cases, achieving a top-ranking accuracy of 73%. Conclusions: These results underscore the robust capabilities of the framework, and the enrichment enhances the efficiency of medical experts, enabling them to provide more precise and informed diagnostics. [ABSTRACT FROM AUTHOR]

The prediction of future disease development based on past diagnosis records has gained significant attention due to the growing health awareness among individuals. Recent deep learning-based methods have successfully predicted disease development by establishing relationships for each diagnosis record and extracting features from a patient's past diagnoses in chronological order. However, most of these models have ignored the connections between identified diseases and low-risk diseases, leading to bottlenecks and limitations. In addition, the extraction of temporal characteristics is also hindered by the problem of global feature forgetting. To address these issues, we propose a global context-aware net using disease relationship reasoning and attention-based feature fusion, abbreviated as DRR. Our model incorporates a disease relationship reasoning module that enhances the model's attention to the relationship between confirmed diseases and low-risk diseases, thereby alleviating the current model's bottlenecks. Moreover, we have established a global graph-based feature fusion module that integrates global graph-based features with temporal features, mitigating the issue of global feature forgetting. Extensive experiments were conducted on two publicly available datasets, and the experiments show that our method achieves advanced performance. [ABSTRACT FROM AUTHOR]

As an effective and efficient discriminative learning method, the broad learning system (BLS) has received increasing attention due to its outstanding performance without large computational resources. The standard BLS is derived under the minimum mean square error (MMSE) criterion, while MMSE is with poor performance when dealing with imbalanced data. However, imbalanced data are widely encountered in real-world applications. To address this issue, a novel cost-sensitive BLS algorithm (CS-BLS) is proposed. In the CS-BLS, many variations can be adopted, and CS-BLS with weighted cross-entropy is analyzed in this paper. Weighted penalty factors are used in CS-BLS to constrain the contribution of each sample in different classes. The samples in minor classes are allocated higher weights to increase their contributions. Four different weight calculation methods are adopted to the CS-BLS, and thus, four CS-BLS methods are proposed: Log-CS-BLS, Lin-CS-BLS, Sqr-CS-BLS, and EN-CS-BLS. Experiments based on artificially imbalanced datasets of MNIST and small NORB are firstly conducted and compared with the standard BLS. The results show that the proposed CS-BLS methods have better generalization and robustness than the standard BLS. Then, experiments on a real ultrasound breast image dataset are conducted, and the results demonstrate that the proposed CS-BLS methods are effective in actual medical diagnosis. [ABSTRACT FROM AUTHOR]

The Neutrosophic Set (N s e t) represents the uncertainty in data with fuzzy attributes beyond true and false values independently. The problem arises when the summation of true (T r) , false (F a) , and indeterminacy I n values crosses the membership value of one, that is, T r + I n + F a < 1 . It becomes more crucial during decision-making processes like medical diagnoses or any data sets where T r + I n + F a < 1 . To achieve this goal, the F N s e t is recently introduced. This study employs the Interval-Valued Fermatean Neutrosophic Set ( I V F N s e t ) as its chosen framework to address instances of partial ignorance within the domains of truth, falsehood, or uncertainty. This selection stands out due to its unique approach to managing such complexities within multi-decision processes when compared to alternative methodologies. Furthermore, the proposed method reduces the propensity for information loss often encountered in other techniques. IVFNS excels at preserving intricate relationships between variables even when dealing with incomplete or vague information. In the present work, we introduce the I V F N s e t , which deals with partial ignorance in true, false, or uncertain regions independently for multi-decision processes. The I V F N s e t contains the interval-valued T r m e m b e r s h i p value, I n m e m b e r s h i p value, and F a m e m b e r s h i p for knowledge representation. The algebraic properties and set theory between the interval-valued F N s e t have also been presented with an illustrative example. [ABSTRACT FROM AUTHOR]

The Molodtsov-initiated soft set theory plays an important role as a powerful mathematical tool for handling uncertainty. As an extension of the soft set, the fuzzy soft set can be seen to be more generic and flexible than utilizing the soft set only that fails to represent problem parameters fuzziness. Through this progress, the fuzzy soft set theory cannot deal with decision-making problems involving multi-attribute sets, bipolarity, or some effective considered parameters. Therefore, the goal of this article is to adapt effectiveness and bipolarity concepts with the multi-fuzzy soft set of order n. One can see that this approach generates a novel, extended, effective decision-making environment that is more applicable than any previously introduced one. In addition, types, concepts, and operations of effective bipolar-valued multi-fuzzy soft sets of dimension n are provided, each with an example. Furthermore, properties like absorption, associative, distributive, commutative, and De Morgan's laws of those new sets are investigated. Moreover, a decision-making methodology under effective bipolar-valued multi-fuzzy soft settings is established. This technique facilitates reaching the final decision that this student is qualified to take a certain education level, or this patient is suffering from a certain disease, etc. In addition, a case study represented in a medical diagnosis example is discussed in detail to make the proposed algorithm clearer. Applying matrix techniques in this example as well as using MATLAB®, not only makes it easier and faster in doing calculations, but also gives more accurate, optimal, and effective decisions. Finally, the sensitivity analysis, as well as a comparison with the existing methods, are conducted in detail and are summarized in a chart to show the difference between them and the current one. [ABSTRACT FROM AUTHOR]

In this paper, we study the matrix representation of fuzzy soft sets, complement of fuzzy soft sets, product of fuzzy soft matrices and the application of fuzzy soft matrices in medical diagnosis presented by Lavanya and Akila. Additionally, a new method (max-min average) based on fuzzy reference function is introduced instead of the max-product method by Lavanya and Akila to extend Sanchez's technique for decision making problems in medical diagnosis. Using the same data by Lavanya and Akila, the result shows that the new method gives more information about the medical status of the patients being considered in relation to a set of diseases. [ABSTRACT FROM AUTHOR]

Machine learning in the medical area has become a very important requirement. The healthcare professional needs useful tools to diagnose medical illnesses. Classifiers are important to provide tools that can be useful to the health professional for this purpose. However, questions arise: which classifier to use? What metrics are appropriate to measure the performance of the classifier? How to determine a good distribution of the data so that the classifier does not bias the medical patterns to be classified in a particular class? Then most important question: does a classifier perform well for a particular disease? This paper will present some answers to the questions mentioned above, making use of classification algorithms widely used in machine learning research with datasets relating to medical illnesses under the supervised learning scheme. In addition to state-of-the-art algorithms in pattern classification, we introduce a novelty: the use of meta-learning to determine, a priori, which classifier would be the ideal for a specific dataset. The results obtained show numerically and statistically that there are reliable classifiers to suggest medical diagnoses. In addition, we provide some insights about the expected performance of classifiers for such a task. [ABSTRACT FROM AUTHOR]

Breast cancer (BC) is a type of cancer suffered by adult females worldwide. A late diagnosis of BC leads to death, so early diagnosis is essential for saving lives. There are many methods of diagnosing BC, including surgical open biopsy (SOB), which however constitutes an intense workload for pathologists to follow SOB and additionally takes a long time. Therefore, artificial intelligence systems can help by accurately diagnosing BC earlier; it is a tool that can assist doctors in making sound diagnostic decisions. In this study, two proposed approaches were applied, each with two systems, to diagnose BC in a dataset with magnification factors (MF): 40×, 100×, 200×, and 400×. The first proposed method is a hybrid technology between CNN (AlexNet and GoogLeNet) models that extracts features and classify them using the support vector machine (SVM). Thus, all BC datasets were diagnosed using AlexNet + SVM and GoogLeNet + SVM. The second proposed method diagnoses all BC datasets by ANN based on combining CNN features with handcrafted features extracted using the fuzzy color histogram (FCH), local binary pattern (LBP), and gray level co-occurrence matrix (GLCM), which collectively is called fusion features. Finally, the fusion features were fed into an artificial neural network (ANN) for classification. This method has proven its superior ability to diagnose histopathological images (HI) of BC accurately. The ANN algorithm based on fusion features achieved results of 100% for all metrics with the 400× dataset. [ABSTRACT FROM AUTHOR]

Histopathology refers to the examination by a pathologist of biopsy samples. Histopathology images are captured by a microscope to locate, examine, and classify many diseases, such as different cancer types. They provide a detailed view of different types of diseases and their tissue status. These images are an essential resource with which to define biological compositions or analyze cell and tissue structures. This imaging modality is very important for diagnostic applications. The analysis of histopathology images is a prolific and relevant research area supporting disease diagnosis. In this paper, the challenges of histopathology image analysis are evaluated. An extensive review of conventional and deep learning techniques which have been applied in histological image analyses is presented. This review summarizes many current datasets and highlights important challenges and constraints with recent deep learning techniques, alongside possible future research avenues. Despite the progress made in this research area so far, it is still a significant area of open research because of the variety of imaging techniques and disease-specific characteristics. [ABSTRACT FROM AUTHOR]

Regions detection has an influence on the better treatment of brain tumors. Existing algorithms in the early detection of tumors are difficult to diagnose reliably. In this paper, we introduced a new robust algorithm using three methods for the classification of brain disease. The first method is Wavelet-Generalized Autoregressive Conditional Heteroscedasticity-K-Nearest Neighbor (W-GARCH-KNN). The Two-Dimensional Discrete Wavelet (2D-DWT) is utilized as the input images. The sub-banded wavelet coefficients are modeled using the GARCH model. The features of the GARCH model are considered as the main property vector. The second method is the Developed Wavelet-GARCH-KNN (D-WGK), which solves the incompatibility of the WGK method for the use of a low pass sub-band. The third method is the Wavelet Local Linear Approximation (LLA)-KNN, which we used for modeling the wavelet sub-bands. The extracted features were applied separately to determine the normal image or brain tumor based on classification methods. The classification was performed for the diagnosis of tumor types. The empirical results showed that the proposed algorithm obtained a high rate of classification and better practices than recently introduced algorithms while requiring a smaller number of classification features. According to the results, the Low-Low sub-bands are not adopted with the GARCH model; therefore, with the use of homomorphic filtering, this limitation is overcome. The results showed that the presented Local Linear (LL) method was better than the GARCH model for modeling wavelet sub-bands. [ABSTRACT FROM AUTHOR]

Diabetic retinopathy (DR) is a leading cause of blindness in middle-aged diabetic patients. Regular screening for DR using fundus imaging aids in detecting complications and delays the progression of the disease. Because manual screening takes time and is subjective, deep learning has been used to help graders. Pre-trained or brute force CNN models are used in existing DR grading CNN-based approaches that are not suited to fundus image complexity. To solve this problem, we present a method for automatically customizing CNN models based on fundus image lesions. It uses k-medoid clustering, principal component analysis (PCA), and inter-class and intra-class variations to determine the CNN model's depth and width. The designed models are lightweight, adapted to the internal structures of fundus images, and encode the discriminative patterns of DR lesions. The technique is validated on a local dataset from King Saud University Medical City, Saudi Arabia, and two challenging Kaggle datasets: EyePACS and APTOS2019. The auto-designed models outperform well-known pre-trained CNN models such as ResNet152, DenseNet121, and ResNeSt50, as well as Google's AutoML and Auto-Keras models based on neural architecture search (NAS). The proposed method outperforms current CNN-based DR screening methods. The proposed method can be used in various clinical settings to screen for DR and refer patients to ophthalmologists for further evaluation and treatment. [ABSTRACT FROM AUTHOR]

Cavum septum pellucidum (CSP) is one of the most important physiologic structures that should be detected in Ultrasound (US) scanning for the normal development of the fetal central nervous system. However, manual measurement of CSP is still a difficult and time-consuming task due to the high noise of US images, even for experienced sonographers. Especially considering that maternal mortality remains high in many developing countries, a data-driven system with a medical diagnosis can help sonographers and obstetricians make decisions rapidly and improve their work efficiency. In this study, we propose a novel data-driven system based on deep learning for the diagnosis of CSP called CA-Unet, which consists of a channel attention network to segment the CSP and a post-processing module to measure and diagnose the anomalies of CSP. We collected the US data from three hospitals in China from 2012 to 2018 year to validate the effectiveness of our system. Experiments on a fetal US dataset demonstrated that our proposed system is able to help doctors make decisions and has achieved the highest precision of 79.5% and the largest Dice score of 77.5% in the segmentation of CSP. [ABSTRACT FROM AUTHOR]

As the extension of the fuzzy sets (FSs) theory, the intuitionistic fuzzy sets (IFSs) play an important role in handling the uncertainty under the uncertain environments. The Pythagoreanfuzzy sets (PFSs) proposed by Yager in 2013 can deal with more uncertain situations than intuitionistic fuzzy sets because of its larger range of describing the membership grades. How to measure the distance of Pythagorean fuzzy sets is still an open issue. Jensen–Shannon divergence is a useful distance measure in the probability distribution space. In order to efficiently deal with uncertainty in practical applications, this paper proposes a new divergence measure of Pythagorean fuzzy sets, which is based on the belief function in Dempster–Shafer evidence theory, and is called PFSDM distance. It describes the Pythagorean fuzzy sets in the form of basic probability assignments (BPAs) and calculates the divergence of BPAs to get the divergence of PFSs, which is the step in establishing a link between the PFSs and BPAs. Since the proposed method combines the characters of belief function and divergence, it has a more powerful resolution than other existing methods. Additionally, an improved algorithm using PFSDM distance is proposed in medical diagnosis, which can avoid producing counter-intuitive results especially when a data conflict exists. The proposed method and the magnified algorithm are both demonstrated to be rational and practical in applications. [ABSTRACT FROM AUTHOR]

In this paper, the diagnosis of the manufacturing process under the indeterminate environment is presented. The similarity measure index was used to find the probability of the in-control and the out-of-control of the process. The average run length (ARL) was also computed for various values of specified parameters. An example from the Juice Company is considered under the indeterminate environment. From this study, it is concluded that the proposed diagnosis scheme under the neutrosophic statistics is quite simple and effective for the current state of the manufacturing process under uncertainty. The use of the proposed method under the uncertainty environment in the Juice Company may eliminate the non-conforming items and alternatively increase the profit of the company. [ABSTRACT FROM AUTHOR]

An original innovative two-dimensional (2D) multi-layer model based on the Maxwell–Fourier method for the diagnosis of a polymer exchange membrane (PEM) fuel cell (FC) stack is presented. It is possible to determine the magnetic field distribution generated around the PEMFC stack from the (non-)homogenous current density distribution inside the PEMFC stack. Analysis of the magnetic field distribution can indicate whether the FC is healthy or faulty. In this way, an explicit, accurate and fast analytical model can allow the health state of an FC to be studied. To evaluate the capacity and the efficiency of the 2D analytical model, the distribution of local quantities (i.e., magnetic vector potential and magnetic field) in a PEMFC stack has been validated with those obtained by the 2D finite-element analysis (FEA). The comparisons demonstrate excellent results both in terms of amplitude and waveform. The validation of this 2D analytical model is essential for the subsequent generation of an inverse model useful for the diagnosis of a PEMFC. [ABSTRACT FROM AUTHOR]

Due to the increasing complexity of the entire satellite system and the deteriorating orbital environment, multiple independent single faults may occur simultaneously in the satellite power system. However, two stumbling blocks hinder the effective diagnosis of simultaneous-fault, namely, the difficulty of obtaining the simultaneous-fault data and the extremely complicated mapping of the simultaneous-fault modes to the sensor data. To tackle the challenges, a fault diagnosis strategy based on a novel rough set model is proposed. Specifically, a novel rough set model named FNζDTRS by introducing a concise loss function matrix and fuzzy neighborhood relationship is proposed to accurately mine and characterize the relationship between fault and data. Furthermore, an attribute rule-based fault matching strategy is designed without using simultaneous-fault data as training samples. The numerical experiments demonstrate the effectiveness of the FNζDTRS model, and the diagnosis experiments performed on a satellite power system illustrate the superiority of the proposed approach. [ABSTRACT FROM AUTHOR]

Pattern recognition is the computerized identification of shapes, designs, and reliabilities in information. It has applications in information compression, machine learning, statistical information analysis, signal processing, image analysis, information retrieval, bioinformatics, and computer graphics. Similarly, a medical diagnosis is a procedure to illustrate or identify diseases or disorders, which would account for a person's symptoms and signs. Moreover, to illustrate the relationship between any two pieces of intuitionistic hesitant fuzzy (IHF) information, the theory of generalized dice similarity (GDS) measures played an important and valuable role in the field of genuine life dilemmas. The main influence of GDS measures is that we can easily obtain a lot of measures by using different values of parameters, which is the main part of every measure, called DGS measures. The major influence of this theory is to utilize the well-known and valuable theory of dice similarity measures (DSMs) (four different types of DSMs) under the assumption of the IHF set (IHFS), because the IHFS covers the membership grade (MG) and non-membership grade (NMG) in the form of a finite subset of [0, 1], with the rule that the sum of the supremum of the duplet is limited to [0, 1]. Furthermore, we pioneered the main theory of generalized DSMs (GDSMs) computed based on IHFS, called the IHF dice similarity measure, IHF weighted dice similarity measure, IHF GDS measure, and IHF weighted GDS measure, and computed their special cases with the help of parameters. Additionally, to evaluate the proficiency and capability of pioneered measures, we analyzed two different types of applications based on constructed measures, called medical diagnosis and pattern recognition problems, to determine the supremacy and consistency of the presented approaches. Finally, based on practical application, we enhanced the worth of the evaluated measures with the help of a comparative analysis of proposed and existing measures. [ABSTRACT FROM AUTHOR]

Medical diagnosis has been recognized as one of the key processes in clinical medicine, which determines diseases from some given symptoms. Nonetheless, previous works about medical diagnosis have some drawbacks because medical data are usually fuzzy, uncertain, incomplete and imprecise. To achieve the optimal medical diagnosis decision by reducing cost and enhancing accuracy, this paper develops a new method named interval three-way concept lattice model. Firstly, we redefine the decision rules and metric function of three-way decision based on interval concept lattice. Secondly, we build a visualized hierarchical structure of relationship between concepts through interval concept construction algorithm which helps us to make decision preferably and clearly. Finally, we establish a dynamic strategy optimization model for medical diagnosis decision making. In addition, a medical case demonstrates the effectiveness and feasibility of this proposed model. [ABSTRACT FROM AUTHOR]

Professional knowledge is highlighted as an important prerequisite of both medical doctors and teachers. Based on recent conceptions of professional knowledge in these fields, knowledge can be differentiated within several aspects. However, these knowledge aspects are currently conceptualized differently across different domains and projects. Thus, this paper describes recent frameworks for professional knowledge in medical and educational sciences, which are then integrated into an interdisciplinary two-dimensional model of professional knowledge that can help to align terminology in both domains and compare research results. The models' two dimensions differentiate between cognitive types of knowledge and content-related knowledge facets and introduces a terminology for all emerging knowledge aspects. The models' applicability for medical and educational sciences is demonstrated in the context of diagnosis by describing prototypical diagnostic settings for medical doctors as well as for teachers, which illustrate how the framework can be applied and operationalized in these areas. Subsequently, the role of the different knowledge aspects for acting and the possibility of transfer between different content areas are discussed. In conclusion, a possible extension of the model along a "third dimension" that focuses on the effects of growing expertise on professional knowledge over time is proposed and issues for further research are outlined. [ABSTRACT FROM AUTHOR]

Alzheimer's Disease (AD) is a highly prevalent condition and most of the people suffering from it receive the diagnosis late in the process. The diagnosis is currently established following an evaluation of the protein biomarkers in cerebrospinal fluid (CSF), brain imaging, cognitive tests, and the medical history of the individuals. While diagnostic tools based on CSF collections are invasive, the tools used for acquiring brain scans are expensive. Taking these into account, an early predictive system, based on Artificial Intelligence (AI) approaches, targeting the diagnosis of this condition, as well as the identification of lead biomarkers becomes an important research direction. In this survey, we review the state-of-the-art research on machine learning (ML) techniques used for the detection of AD and Mild Cognitive Impairment (MCI). We attempt to identify the most accurate and efficient diagnostic approaches, which employ ML techniques and therefore, the ones most suitable to be used in practice. Research is still ongoing to determine the best biomarkers for the task of AD classification. At the beginning of this survey, after an introductory part, we enumerate several available resources, which can be used to build ML models targeting the diagnosis and classification of AD, as well as their main characteristics. After that, we discuss the candidate markers which were used to build AI models with the best results in terms of diagnostic accuracy, as well as their limitations. [ABSTRACT FROM AUTHOR]

Several neurological illnesses and diseased sites have been studied, along with the anatomical framework of the brain, using structural MRI (sMRI). It is critical to diagnose Alzheimer's disease (AD) patients in a timely manner to implement preventative treatments. The segmentation of brain anatomy and categorization of AD have received increased attention since they can deliver good findings spanning a vast range of information. The first research gap considered in this work is the real-time efficiency of OTSU segmentation, which is not high, despite its simplicity and good accuracy. A second issue is that feature extraction could be automated by implementing deep learning techniques. To improve picture segmentation's real-timeliness, enhanced fuzzy elephant herding optimization (EFEHO) was used for OTSU segmentation, and named EFEHO-OTSU. The main contribution of this work is twofold. One is utilizing EFEHO in the recommended technique to seek the optimal segmentation threshold for the OTSU method. Second, dual attention multi-instance deep learning network (DA-MIDL) is recommended for the timely diagnosis of AD and its prodromal phase, mild cognitive impairment (MCI). Tests show that this technique converges faster and takes less time than the classic OTSU approach without reducing segmentation performance. This study develops a valuable tool for quick picture segmentation with good real-time efficiency. Compared to numerous conventional techniques, the suggested study attains improved categorization performance regarding accuracy and transferability. [ABSTRACT FROM AUTHOR]

The burgeoning advances in high-throughput technologies have posed a great challenge to the identification of novel biomarkers for diagnosing, by contemporary models and methods, through bioinformatics-driven analysis. Diagnostic performance metrics such as the partial area under the R O C ( p A U C ) indexes exhibit limitations to analysing genomic data. Among other issues, the inability to differentiate between biomarkers whose R O C curves cross each other with the same p A U C value, the inappropriate expression of non-concave R O C curves, and the lack of a convenient interpretation, restrict their use in practice. Here, we have proposed the fitted partial area index ( F p A U C ), which is computable through an algorithm valid for any R O C curve shape, as an alternative performance summary for the evaluation of highly sensitive biomarkers. The proposed approach is based on fitter upper and lower bounds of the p A U C in a high-sensitivity region. Through variance estimates, simulations, and case studies for diagnosing leukaemia, and ovarian and colon cancers, we have proven the usefulness of the proposed metric in terms of restoring the interpretation and improving diagnostic accuracy. It is robust and feasible even when the R O C curve shows hooks, and solves performance ties between competitive biomarkers. [ABSTRACT FROM AUTHOR]

Cardiovascular Diseases (CVDs) are a leading cause of death globally. In CVDs, the heart is unable to deliver enough blood to other body regions. As an effective and accurate diagnosis of CVDs is essential for CVD prevention and treatment, machine learning (ML) techniques can be effectively and reliably used to discern patients suffering from a CVD from those who do not suffer from any heart condition. Namely, machine learning algorithms (MLAs) play a key role in the diagnosis of CVDs through predictive models that allow us to identify the main risks factors influencing CVD development. In this study, we analyze the performance of ten MLAs on two datasets for CVD prediction and two for CVD diagnosis. Algorithm performance is analyzed on top-two and top-four dataset attributes/features with respect to five performance metrics –accuracy, precision, recall, f1-score, and roc-auc—using the train-test split technique and k-fold cross-validation. Our study identifies the top-two and top-four attributes from CVD datasets analyzing the performance of the accuracy metrics to determine that they are the best for predicting and diagnosing CVD. As our main findings, the ten ML classifiers exhibited appropriate diagnosis in classification and predictive performance with accuracy metric with top-two attributes, identifying three main attributes for diagnosis and prediction of a CVD such as arrhythmia and tachycardia; hence, they can be successfully implemented for improving current CVD diagnosis efforts and help patients around the world, especially in regions where medical staff is lacking. [ABSTRACT FROM AUTHOR]

Automated diagnosis systems aim to reduce the cost of diagnosis while maintaining the same efficiency. Many methods have been used for breast cancer subtype classification. Some use single data source, while others integrate many data sources, the case that results in reduced computational performance as opposed to accuracy. Breast cancer data, especially biological data, is known for its imbalance, with lack of extensive amounts of histopathological images as biological data. Recent studies have shown that cascade Deep Forest ensemble model achieves a competitive classification accuracy compared with other alternatives, such as the general ensemble learning methods and the conventional deep neural networks (DNNs), especially for imbalanced training sets, through learning hyper-representations through using cascade ensemble decision trees. In this work, a cascade Deep Forest is employed to classify breast cancer subtypes, IntClust and Pam50, using multi-omics datasets and different configurations. The results obtained recorded an accuracy of 83.45% for 5 subtypes and 77.55% for 10 subtypes. The significance of this work is that it is shown that using gene expression data alone with the cascade Deep Forest classifier achieves comparable accuracy to other techniques with higher computational performance, where the time recorded is about 5 s for 10 subtypes, and 7 s for 5 subtypes. [ABSTRACT FROM AUTHOR]

This article presents a novel hybrid classification paradigm for medical diagnoses and prognoses prediction. The core mechanism of the proposed method relies on a centroid classification algorithm whose logic is exploited to formulate the classification task as a real-valued optimisation problem. A novel metaheuristic combining the algorithmic structure of Swarm Intelligence optimisers with the probabilistic search models of Estimation of Distribution Algorithms is designed to optimise such a problem, thus leading to high-accuracy predictions. This method is tested over 11 medical datasets and compared against 14 cherry-picked classification algorithms. Results show that the proposed approach is competitive and superior to the state-of-the-art on several occasions. [ABSTRACT FROM AUTHOR]