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Predicting diseases in the early stages is extremely important. By taking advantage of advances in deep learning and fuzzy logic techniques, a new model is proposed in this paper for disease evaluation depending on the adaptive neuro-fuzzy inference system (ANFIS) with a genetic algorithm (GA) for classification, and the pre-trained DenseNet-201 model for feature extraction, in addition to the whale optimization algorithm (WOA) for feature selection. Two medical databases (chest X-ray and MRI brain tumor) for the diagnosis of two disease types were used as input in the suggested model. The optimization of ANFIS parameters was performed by GA to achieve the optimum prediction capability. DenseNet-201 for feature extraction was employed to obtain better classification accuracy. Having more features sometimes leads to lower accuracy, and this issue can be rectified using a feature selection strategy WOA which gave good results. The proposed model was evaluated utilizing statistical metrics root mean square error (RMSE), mean square error (MSE), standard deviation (STD), and coefficient of determination ( R 2 ), and it was compared with the conventional ANFIS model, with the proposed model (ANFIS-GA) showing a superior prediction capability over the ANFIS model. As a result, it can be concluded that the proposed ANFIS-GA model is efficient and has the potential for a robust diseases evaluation with good accuracy. Also, we conclude from this work that integrating optimization algorithms with ANFIS boosts its performance, resulting in a more accurate and reliable model. [ABSTRACT FROM AUTHOR]