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With the continuous development of the Automatic Train Operation (ATO) system in high-speed railways, automatic driving is progressively supplanting manual operations, ushering in a new era of predictability and reliability for high-speed railway transport. Concurrently, the advent of the ATO system provides a notable impact on real-time rescheduling during disruptions, as it equips dispatchers with precise insights into train operation statuses. This paper is dedicated to a thorough analysis of how the transition to automatic driving in train operations influences the real-time rescheduling model. Based on the distinctive impact of the ATO system on real-time rescheduling, we have proposed a mixed-integer linear programming model that combines train re-timing, reordering, and the minimization of passenger delays. To validate the effectiveness of our model, we present several experiments conducted using data from the Beijing–Shanghai high-speed railway line. The results unequivocally demonstrate that our ATO-based model significantly mitigates train delay time, demonstrating its practical value in optimizing high-speed railway operations. [ABSTRACT FROM AUTHOR]