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In recent years, deep learning has been successfully applied to medical image analysis and provided assistance to medical professionals. Machine learning is being used to offer diagnosis suggestions, identify regions of interest in images, or augment data to remove noise. Training models for such tasks require a large amount of labeled data. It is often difficult to procure such data due to the fact that these requires experts to manually label them, in addition to the privacy and legal concerns that limiting their collection. Due to this, creating self-supervision learning methods and domain-adaptation techniques dedicated to this domain is essential. This paper reviews concepts from the field of deep learning and how they have been applied to medical image analysis. We also review the current state of self-supervised learning methods and their applications to medical images. In doing so, we will also present the resource ecosystem of researchers in this field, such as datasets, evaluation methodologies, and benchmarks. [ABSTRACT FROM AUTHOR]

Data normalization is a data preprocessing task and one of the first to be performed during intellectual analysis, particularly in the case of tabular data. The importance of its implementation is determined by the need to reduce the sensitivity of the artificial intelligence model to the values of the features in the dataset to increase the studied model's adequacy. This paper focuses on the problem of effectively preprocessing data to improve the accuracy of intellectual analysis in the case of performing medical diagnostic tasks. We developed a new two-step method for data normalization of numerical medical datasets. It is based on the possibility of considering both the interdependencies between the features of each observation from the dataset and their absolute values to improve the accuracy when performing medical data mining tasks. We describe and substantiate each step of the algorithmic implementation of the method. We also visualize the results of the proposed method. The proposed method was modeled using six different machine learning methods based on decision trees when performing binary and multiclass classification tasks. We used six real-world, freely available medical datasets with different numbers of vectors, attributes, and classes to conduct experiments. A comparison between the effectiveness of the developed method and that of five existing data normalization methods was carried out. It was experimentally established that the developed method increases the accuracy of the Decision Tree and Extra Trees Classifier by 1–5% in the case of performing the binary classification task and the accuracy of the Bagging, Decision Tree, and Extra Trees Classifier by 1–6% in the case of performing the multiclass classification task. Increasing the accuracy of these classifiers only by using the new data normalization method satisfies all the prerequisites for its application in practice when performing various medical data mining tasks. [ABSTRACT FROM AUTHOR]

Today, artificial intelligence (AI) and machine learning (ML) have dramatically advanced in various industries, especially medicine. AI describes computational programs that mimic and simulate human intelligence, for example, a person's behavior in solving problems or his ability for learning. Furthermore, ML is a subset of artificial intelligence. It extracts patterns from raw data automatically. The purpose of this paper is to help researchers gain a proper understanding of machine learning and its applications in healthcare. In this paper, we first present a classification of machine learning-based schemes in healthcare. According to our proposed taxonomy, machine learning-based schemes in healthcare are categorized based on data pre-processing methods (data cleaning methods, data reduction methods), learning methods (unsupervised learning, supervised learning, semi-supervised learning, and reinforcement learning), evaluation methods (simulation-based evaluation and practical implementation-based evaluation in real environment) and applications (diagnosis, treatment). According to our proposed classification, we review some studies presented in machine learning applications for healthcare. We believe that this review paper helps researchers to familiarize themselves with the newest research on ML applications in medicine, recognize their challenges and limitations in this area, and identify future research directions. [ABSTRACT FROM AUTHOR]

Machine learning in the medical area has become a very important requirement. The healthcare professional needs useful tools to diagnose medical illnesses. Classifiers are important to provide tools that can be useful to the health professional for this purpose. However, questions arise: which classifier to use? What metrics are appropriate to measure the performance of the classifier? How to determine a good distribution of the data so that the classifier does not bias the medical patterns to be classified in a particular class? Then most important question: does a classifier perform well for a particular disease? This paper will present some answers to the questions mentioned above, making use of classification algorithms widely used in machine learning research with datasets relating to medical illnesses under the supervised learning scheme. In addition to state-of-the-art algorithms in pattern classification, we introduce a novelty: the use of meta-learning to determine, a priori, which classifier would be the ideal for a specific dataset. The results obtained show numerically and statistically that there are reliable classifiers to suggest medical diagnoses. In addition, we provide some insights about the expected performance of classifiers for such a task. [ABSTRACT FROM AUTHOR]

Histopathology refers to the examination by a pathologist of biopsy samples. Histopathology images are captured by a microscope to locate, examine, and classify many diseases, such as different cancer types. They provide a detailed view of different types of diseases and their tissue status. These images are an essential resource with which to define biological compositions or analyze cell and tissue structures. This imaging modality is very important for diagnostic applications. The analysis of histopathology images is a prolific and relevant research area supporting disease diagnosis. In this paper, the challenges of histopathology image analysis are evaluated. An extensive review of conventional and deep learning techniques which have been applied in histological image analyses is presented. This review summarizes many current datasets and highlights important challenges and constraints with recent deep learning techniques, alongside possible future research avenues. Despite the progress made in this research area so far, it is still a significant area of open research because of the variety of imaging techniques and disease-specific characteristics. [ABSTRACT FROM AUTHOR]

Pattern recognition is the computerized identification of shapes, designs, and reliabilities in information. It has applications in information compression, machine learning, statistical information analysis, signal processing, image analysis, information retrieval, bioinformatics, and computer graphics. Similarly, a medical diagnosis is a procedure to illustrate or identify diseases or disorders, which would account for a person's symptoms and signs. Moreover, to illustrate the relationship between any two pieces of intuitionistic hesitant fuzzy (IHF) information, the theory of generalized dice similarity (GDS) measures played an important and valuable role in the field of genuine life dilemmas. The main influence of GDS measures is that we can easily obtain a lot of measures by using different values of parameters, which is the main part of every measure, called DGS measures. The major influence of this theory is to utilize the well-known and valuable theory of dice similarity measures (DSMs) (four different types of DSMs) under the assumption of the IHF set (IHFS), because the IHFS covers the membership grade (MG) and non-membership grade (NMG) in the form of a finite subset of [0, 1], with the rule that the sum of the supremum of the duplet is limited to [0, 1]. Furthermore, we pioneered the main theory of generalized DSMs (GDSMs) computed based on IHFS, called the IHF dice similarity measure, IHF weighted dice similarity measure, IHF GDS measure, and IHF weighted GDS measure, and computed their special cases with the help of parameters. Additionally, to evaluate the proficiency and capability of pioneered measures, we analyzed two different types of applications based on constructed measures, called medical diagnosis and pattern recognition problems, to determine the supremacy and consistency of the presented approaches. Finally, based on practical application, we enhanced the worth of the evaluated measures with the help of a comparative analysis of proposed and existing measures. [ABSTRACT FROM AUTHOR]

Alzheimer's Disease (AD) is a highly prevalent condition and most of the people suffering from it receive the diagnosis late in the process. The diagnosis is currently established following an evaluation of the protein biomarkers in cerebrospinal fluid (CSF), brain imaging, cognitive tests, and the medical history of the individuals. While diagnostic tools based on CSF collections are invasive, the tools used for acquiring brain scans are expensive. Taking these into account, an early predictive system, based on Artificial Intelligence (AI) approaches, targeting the diagnosis of this condition, as well as the identification of lead biomarkers becomes an important research direction. In this survey, we review the state-of-the-art research on machine learning (ML) techniques used for the detection of AD and Mild Cognitive Impairment (MCI). We attempt to identify the most accurate and efficient diagnostic approaches, which employ ML techniques and therefore, the ones most suitable to be used in practice. Research is still ongoing to determine the best biomarkers for the task of AD classification. At the beginning of this survey, after an introductory part, we enumerate several available resources, which can be used to build ML models targeting the diagnosis and classification of AD, as well as their main characteristics. After that, we discuss the candidate markers which were used to build AI models with the best results in terms of diagnostic accuracy, as well as their limitations. [ABSTRACT FROM AUTHOR]

Cardiovascular Diseases (CVDs) are a leading cause of death globally. In CVDs, the heart is unable to deliver enough blood to other body regions. As an effective and accurate diagnosis of CVDs is essential for CVD prevention and treatment, machine learning (ML) techniques can be effectively and reliably used to discern patients suffering from a CVD from those who do not suffer from any heart condition. Namely, machine learning algorithms (MLAs) play a key role in the diagnosis of CVDs through predictive models that allow us to identify the main risks factors influencing CVD development. In this study, we analyze the performance of ten MLAs on two datasets for CVD prediction and two for CVD diagnosis. Algorithm performance is analyzed on top-two and top-four dataset attributes/features with respect to five performance metrics –accuracy, precision, recall, f1-score, and roc-auc—using the train-test split technique and k-fold cross-validation. Our study identifies the top-two and top-four attributes from CVD datasets analyzing the performance of the accuracy metrics to determine that they are the best for predicting and diagnosing CVD. As our main findings, the ten ML classifiers exhibited appropriate diagnosis in classification and predictive performance with accuracy metric with top-two attributes, identifying three main attributes for diagnosis and prediction of a CVD such as arrhythmia and tachycardia; hence, they can be successfully implemented for improving current CVD diagnosis efforts and help patients around the world, especially in regions where medical staff is lacking. [ABSTRACT FROM AUTHOR]