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This paper considers a model for the accumulation of mutations in a population of mice with a weakened function of polymerases responsible for correcting DNA copying errors during cell division. The model uses the results of the experiment published by Japanese scientists, which contain data on the accumulation of phenotypic differences in three isolated groups of laboratory mice. We have developed a model for the accumulation of negative mutations. Since the accumulation of phenotypic differences in each of the three groups of mice occurred in its own way, we assumed that these differences were associated with genotypic differences in the zeroth generation and set the inverse problem of determining the initial distribution of these differences. Additional information for solving the inverse problem was a set of experimental data on the number of mutant lines and the number of individuals in each group of mice. The results obtained confirmed our assumption. [ABSTRACT FROM AUTHOR]

The paper considers the features of numerical reconstruction of the advection coefficient when solving the coefficient inverse problem for a nonlinear singularly perturbed equation of the reaction-diffusion-advection type. Information on the position of a reaction front is used as data of the inverse problem. An important question arises: is it possible to obtain a mathematical connection between the unknown coefficient and the data of the inverse problem? The methods of asymptotic analysis of the direct problem help to solve this question. But the reduced statement of the inverse problem obtained by the methods of asymptotic analysis contains a nonlinear integral equation for the unknown coefficient. The features of its solution are discussed. Numerical experiments demonstrate the possibility of solving problems of such class using the proposed methods. [ABSTRACT FROM AUTHOR]