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The problem of mycotoxin presence in animal feed and the consequences that arise due to this, represent a great challenge for anyone encountering them. In the chain which includes studies from prevention to treatment, a very important place and a frequent source of confusion is the process of diagnosing diseases caused by mycotoxins. The aim of this paper is to present a long experience of the team of experts at the Institute of Veterinary Medicine of Serbia in Belgrade, who follows this issue in terms of clinical manifestations of mycotoxicoses in different animal species, pathomorphological and pathohistological changes that characterize them, and laboratory analysis of feed which is the source of those biological hazards and natural contaminants. Based on the findings it could be concluded that mycotoxin contamination is common. Although these levels usually do not exceed the limits laid by the legislation, considering the cumulative effects and possible chronic exposure of animals to their harmful influence, appropriate and competent approach is necessary. Namely, even when direct losses, such as animals' mortality, are not present, indirect losses, due to a drop of animal performances and production, as well as the occurrence of secondary infections, should not be neglected. [ABSTRACT FROM AUTHOR]