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Your search keyword '"Alexandrou, Andreas"' showing total 18 results
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18 results on '"Alexandrou, Andreas"'

8. Updates on the treatment of invasive breast cancer: Quo Vadimus?

Author

Nigdelis, Meletios P., Karamouzis, Michalis V., Kontos, Michael, Alexandrou, Andreas, Goulis, Dimitrios G., and Lambrinoudaki, Irene

Subjects
*BREAST cancer, *TRIPLE-negative breast cancer, *CYCLIN-dependent kinase inhibitors, *HORMONE receptor positive breast cancer, *TREATMENT effectiveness, *SENTINEL lymph nodes
Abstract

Breast cancer is a common malignancy among women. Despite an increase in incidence, breast cancer mortality has drastically dropped over the last 20 years. This change has been attributed to advances in screening, diagnosis, and treatment. This review summarises recent updates in the clinical approach to breast cancer. Advances in genetics have facilitated the stratification of the risk of recurrence in early-stage breast cancer. Advances in biology have led to the development of novel therapies (poly-ADP-ribose polymerase inhibitors, cyclin-dependent kinase 4/6 inhibitors, HER2 targeted agents). Their combination with endocrine (tamoxifen, aromatase inhibitors, GnRH-analogues, fulvestrant) and systematic therapy (anthracyclines, taxanes) in early and advanced disease have improved clinical outcomes. In the near future, neoadjuvant strategies in specific breast cancer subgroups (triple-negative breast cancers) and novel strategies (immune-modulatory agents) could further improve histopathological responses and survival. Radical mastectomies have been widely replaced by breast-conserving operations, while the traditional axillary dissection is being replaced with sentinel node techniques. Breast cancer therapeutics represents a great challenge due to patients' heterogeneous molecular and clinical characteristics, while the identification of reliable and easily reproducible predictive factors could further improve individualized treatment. [ABSTRACT FROM AUTHOR]

Published
2021
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9. Therapeutic strategies for type 2 diabetes mellitus in women after menopause.

Author

Paschou, Stavroula A., Marina, Ljiljana V., Spartalis, Eleftherios, Anagnostis, Panagiotis, Alexandrou, Andreas, Goulis, Dimitrios G., and Lambrinoudaki, Irene

Subjects
*TYPE 2 diabetes, *PREMATURE menopause, *GLUCAGON-like peptide-1 receptor, *DIABETES in women, *GLUCAGON-like peptide-1 agonists, *FOOD habits, *MENOPAUSE
Abstract

As type 2 diabetes mellitus (T2DM) is affected by both chronological and ovarian ageing, it is common in postmenopausal women. This review analyses and critically appraises the literature regarding the optimal therapeutic strategies for T2DM in women after menopause. Lifestyle interventions, including changes in dietary habits and physical exercise in everyday life targeting a modest weight loss (5%), represent the cornerstone of management. Limited intake of alcohol and sodium, as well as smoking cessation, are additional lifestyle changes for both endothelial and bone health. Regarding medications, postmenopausal women should be initially treated with metformin, concurrently with lifestyle intervention. If glycosylated haemoglobin (HbA1c) remains over the target level (usually ≥7%), dipeptidyl peptidase-4 inhibitors (DPP-4i) or glucagon-like peptide-1 receptor agonists (GLP-1RA) should be preferred. Thiazolidinediones (TZDs) and canagliflozin should be avoided in postmenopausal women with increased fracture risk. Insulin should be used with caution to avoid hypoglycaemia. Bariatric surgery is a well established and effective therapeutic option for both weight loss and glycaemic control in very obese patients with T2DM; however, metabolic benefits should be balanced against nutritional deficiencies that often present after surgery. Proper control of hypertension, with avoidance of hypotension, is of great importance as a measure against falls. Annual tests for retinopathy and neuropathy are crucial for the same reason. Menopausal hormone therapy (MHT) has a beneficial effect on glucose homeostasis, reduces the risk of new-onset T2DM and improves glucose control in women with T2DM. T2DM has been considered a cardiovascular disease equivalent, which meant that postmenopausal women with the disease could not take MHT but current evidence supports an individualised approach to this issue. Therapeutic strategies for women with T2DM after menopause should aim to maximise benefits for metabolic, cardiovascular and bone health with the minimum of adverse effects, bearing in mind that most women will spend more than one-third of their life being of postmenopausal status. [ABSTRACT FROM AUTHOR]

Published
2019
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14. Calcium metabolism in relation to subclinical arterial stiffness in asymptomatic, non-diabetic postmenopausal women.

Author

Karopoulou, Evaggelia, Lambrinoudaki, Irene, Pliatsika, Paraskevi, Tsoltos, Nikolaos, Rizos, Demetrios, Augoulea, Areti, Kaparos, Georgios, Alexandrou, Andreas, Stamatelopoulos, Kimon, and Mishra, Gita

Subjects
*CALCIUM metabolism, *ARTERIAL diseases, *POSTMENOPAUSE, *OSTEOCLASIS, *BONE resorption, CARDIOVASCULAR disease related mortality
Published
2017
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17. Vertebral fracture prevalence among Greek healthy middle-aged postmenopausal women: association with demographics, anthropometric parameters and bone mineral density.

Author

Armeni, Eleni, Flokatoula, Maria, Pliatsika, Paraskevi, Antoniou, Aris, Augoulea, Areti, Alexandrou, Andreas, Creatsa, Maria, Panoulis, Constantinos, Papacharalambous, Xenofon, and Lambrinoudaki, Irene

Subjects
*VERTEBRAL fractures, *BONE density, *POSTMENOPAUSE, *DISEASE prevalence, *WOMEN'S health, *DEMOGRAPHY
Published
2015
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18. The development of mood disturbances is associated with levels of circulating androgen in young postmenopausal women.

Author

Armeni, Eleni, Bouziou, Georgia, Spyropoulou, Areti, Koundi, Kalliopi, Rizos, Demetrios, Augoulea, Areti, Alexandrou, Andreas, Creatsa, Maria, Panoulis, Constantinos, Dendrinos, Spyridon, Leonadrou, Angeliki, Zervas, Ioannis, and Lambrinoudaki, Irene

Subjects
*AFFECTIVE disorders, *ANDROGENS, *POSTMENOPAUSE, *DISEASES in middle-aged women, *AGING, *BRAIN, *ESTROGEN
Published
2015
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