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4 results on '"Allert, Stefanie"'

1. Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis

Author

Valentine, Marisa, primary, Rudolph, Paul, additional, Dietschmann, Axel, additional, Tsavou, Antzela, additional, Mogavero, Selene, additional, Lee, Sejeong, additional, Priest, Emily L., additional, Zhurgenbayeva, Gaukhar, additional, Jablonowski, Nadja, additional, Timme, Sandra, additional, Eggeling, Christian, additional, Allert, Stefanie, additional, Dolk, Edward, additional, Naglik, Julian R., additional, Figge, Marc T., additional, Gresnigt, Mark S., additional, and Hube, Bernhard, additional

Published
2024
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2. Survival Strategies of Pathogenic Candida Species in Human Blood Show Independent and Specific Adaptations

Author

Kämmer, Philipp, primary, McNamara, Sylvie, additional, Wolf, Thomas, additional, Conrad, Theresia, additional, Allert, Stefanie, additional, Gerwien, Franziska, additional, Hünniger, Kerstin, additional, Kurzai, Oliver, additional, Guthke, Reinhard, additional, Hube, Bernhard, additional, Linde, Jörg, additional, and Brunke, Sascha, additional

Published
2020
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3. Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers

Author

Allert, Stefanie, primary, Förster, Toni M., additional, Svensson, Carl-Magnus, additional, Richardson, Jonathan P., additional, Pawlik, Tony, additional, Hebecker, Betty, additional, Rudolphi, Sven, additional, Juraschitz, Marc, additional, Schaller, Martin, additional, Blagojevic, Mariana, additional, Morschhäuser, Joachim, additional, Figge, Marc Thilo, additional, Jacobsen, Ilse D., additional, Naglik, Julian R., additional, Kasper, Lydia, additional, Mogavero, Selene, additional, and Hube, Bernhard, additional

Published
2018
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4. Survival Strategies of Pathogenic CandidaSpecies in Human Blood Show Independent and Specific Adaptations

Author

Kämmer, Philipp, McNamara, Sylvie, Wolf, Thomas, Conrad, Theresia, Allert, Stefanie, Gerwien, Franziska, Hünniger, Kerstin, Kurzai, Oliver, Guthke, Reinhard, Hube, Bernhard, Linde, Jörg, and Brunke, Sascha

Abstract

To ensure their survival, pathogens have to adapt immediately to new environments in their hosts, for example, during the transition from the gut to the bloodstream. Here, we investigated the basis of this adaptation in a group of fungal species which are among the most common causes of hospital-acquired infections, the Candidaspecies. On the basis of a human whole-blood infection model, we studied which genes and processes are active over the course of an infection in both the host and four different Candidapathogens. Remarkably, we found that, while the human host response during the early phase of infection is predominantly uniform, the pathogens pursue largely individual strategies and each one regulates genes involved in largely disparate processes in the blood. Our results reveal that C. albicans, C. glabrata, C. parapsilosis, and C. tropicalisall have developed individual strategies for survival in the host. This indicates that their pathogenicity in humans has evolved several times independently and that genes which are central for survival in the host for one species may be irrelevant in another.

Published
2020
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