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Physical activity has been reported to affect endocrine function in elderly men.To establish an association between regular moderate physical activity and endogenous anabolic hormone levels in healthy aging men.Twenty four middle-aged (57.4+/-4.7 years) and 24 elderly (68.3+/-2.6 years) physically active men who in the past 10 years had been regularly bicycling during leisure time were compared with 24 middle-aged (57.9+/-4.0 years) and 24 elderly (67.2+/-1.7 years) sedentary men. Groups did not differ for body composition.Serum dehydroepiandrosterone sulfate (DHEAS), insulin-like growth factor-I (IGF-1), free testosterone (FT), and thyroid hormone levels were assessed.In general, elderly men had lower IGF-1 (P0.001), DHEAS (P=0.013), and triodothyronine levels (P0.001) than their middle-aged counterparts. Independently of age, however, physically active men had on average higher IGF-1 (P=0.031), DHEAS (P=0.001), and triodothyronine serum levels (P0.001) than sedentary men. FT and thyroid stimulating hormone (TSH) serum concentrations did not differ across age groups, but physically active men had lower TSH values than sedentary men (P=0.021).Our results suggest that, in aging men, regular moderate physical activity is associated with higher levels of IGF-1 and DHEAS levels and with thyroid function alterations.

Background: Previous reports have shown elevated plasma total homocysteine (tHcy) levels in elderly person with impaired cognition. Objective: To study the association between cognitive status and plasma tHcy levels in centenarians. Design: Cross-sectional survey. Setting: Centenarians living in two northern Italian provinces. Participants: Thirteen cognitively normal centenarians, ten cognitively impaired not-demented centenarians, and 34 demented centenarians with a clinical diagnosis of Alzheimer's disease (AD). Measurements: Blood levels of homocysteine's biological determinants vitamin B12, folate, and vitamin B6. Results. Elevated plasma tHcy levels ( > 17 μmol/l) were common in the general population (77% of normal centenarians, 100% of cognitively impaired not-demented centenarians. 82% of AD centenarians). Demented centenarians had the lowest folate serum levels. Low or borderline vitamin B12 serum levels (< 221 pmol/l) and low vitamin B6 plasma levels (< 11.7 nmol/l) were found in 33 and 66% of all centenarians independently of cognitive status. Among demented centenarians only plasma tHcy correlated inversely with both serum vitamin B12 and folate. No significant difference was found for plasma tHcy levels among the three diagnostic groups, even after adjusting for B vitamin levels. Conclusions: Hyperho mocysteinemia is very common among centenarians, probably due to vitamin deficiencies, but does not seem to be associated with cognitive impairment.