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Two clinical presentations of human protothecosis have been reported: localized infections such as cutaneous and subcutaneous infections and bursitis which occur in immunocompetent hosts and usually result from traumatic inoculation, and disseminated infections in immunocompromised hosts. The disseminated presentation occurs in patients with AIDS, transplant recipients, or patients undergoing cancer treatments. Humans are constantly exposed to Prototheca, but some factors seem to increase the pathogenicity such as local or systemic glucocorticoid administration (as in our patient), neoplasia, diabetes mellitus, and acquired immunodeficiency syndrome [3]. Our patient had been on fluconazole therapy without improvement because of the lack of amphotericin B. The best activity against Prototheca seems to be amphotericin B [[1], [5]] as shown in vitro by the antifungal susceptibility test results. [Extracted from the article]