1. Tumor Necrosis Factor-Alpha in Peripical Tissue Exudates of Teeth with Apical Periodontitis.
- Author
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Pezelj-Ribarić, Sonja, Magašić, Karolina, Prpić, Jelena, Miletić, Ivana, and Karlović, Zoran
- Subjects
TUMOR necrosis factors ,ENZYME-linked immunosorbent assay ,TOOTH roots ,RADIOLOGY ,ABSORBENT paper - Abstract
Aim. The aim of this study was to determine tumor necrosis factor-alpha (TNF-α) levels in periapical exudates and to evaluate their relationship with radiological findings. Methodology. Periapical exudates were collected from root canals of 60 single-rooted teeth using absorbent paper points. TNF-α levels were determined by enzyme-linked immunosorbent assays. The samples were divided into three groups according to the periapical radiolucent areas. Results. Nonparametric Kruskal-Wallis test revealed significant differences between TNF-α concentrations in control group (40, 57±28, 15 pg/mL) and group with larger radiolucent areas (2365, 79 ± 582, 95 pg/mL), as well as between control and canals with small radiolucent areas (507, 66 ± 278, 97) (P < .05). Conclusions. The levels of TNF-α increase significantly in teeth with periapical pathosis, from smaller to bigger lesions. This research and its results have shown that objective analysis of the TNF-α levels enables establishment of a relationship between different concentrations of TNF-α and different radiological changes. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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