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Your search keyword '"Eun Ju Shin"' showing total 2 results
Start Over Author "Eun Ju Shin" Journal mediators of inflammation
2 results on '"Eun Ju Shin"'

1. Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis

Author

Eun Ju Shin, Mi Jeong Sung, Hye Jeong Yang, Myung Sunny Kim, and Jin-Taek Hwang

Subjects
Pathology, RB1-214
Abstract

We examined the therapeutic effect of an ethanol extract derived from Boehmeria nivea (Linn.) Gaudich in a mouse model of experimental colitis. Treatment with 70% ethanol extract derived from B. nivea (EBN) at a dose of 100, 200, or 500 mg/(kg·d) improved colon shortening, body weight, the disease activity index (DAI), and histopathological score of DSS-induced colitis mice. DSS significantly increased the levels of cyclooxygenase-(COX-) 2 in colon tissue relative to that of the untreated control group. EBN administered at 100, 200, or 500 mg/(kg·d) reduced COX-2 levels in the DSS-treated mice. In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). Taken together, these data suggest that B. nivea extract is effective in preventing colitis.

Published
2014
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2. Boehmeria nivea Attenuates the Development of Dextran Sulfate Sodium-Induced Experimental Colitis

Author

Hye Jeong Yang, Myung Sunny Kim, Eun Ju Shin, Jin-Taek Hwang, and Mi Jeong Sung

Subjects
Male, Chemokine, Article Subject, medicine.medical_treatment, Immunology, Anti-Inflammatory Agents, Pharmacology, Boehmeria, chemistry.chemical_compound, Mice, medicine, lcsh:Pathology, Animals, Colitis, Interleukin 6, Chemokine CCL2, Ethanol, biology, business.industry, Interleukin-6, Plant Extracts, Monocyte, Therapeutic effect, Dextran Sulfate, Cell Biology, biology.organism_classification, medicine.disease, Mice, Inbred C57BL, Cytokine, medicine.anatomical_structure, chemistry, biology.protein, business, Research Article, lcsh:RB1-214
Abstract

We examined the therapeutic effect of an ethanol extract derived fromBoehmeria nivea(Linn.) Gaudich in a mouse model of experimental colitis. Treatment with 70% ethanol extract derived fromB. nivea(EBN) at a dose of 100, 200, or 500 mg/(kg·d) improved colon shortening, body weight, the disease activity index (DAI), and histopathological score of DSS-induced colitis mice. DSS significantly increased the levels of cyclooxygenase-(COX-) 2 in colon tissue relative to that of the untreated control group. EBN administered at 100, 200, or 500 mg/(kg·d) reduced COX-2 levels in the DSS-treated mice. In addition, EBN decreased the DSS-induced secretion of the inflammatory cytokine interleukin-6 (IL-6) and chemokine monocyte chemotactic protein-1 (MCP-1). Taken together, these data suggest thatB. niveaextract is effective in preventing colitis.

Published
2014

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