1. Inter-scanner differences in in vivo QCT measurements of the density and strength of the proximal femur remain after correction with anthropomorphic standardization phantoms
- Author
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Carpenter, R Dana, Saeed, Isra, Bonaretti, Serena, Schreck, Carole, Keyak, Joyce H, Streeper, Timothy, Harris, Tamara B, and Lang, Thomas F
- Subjects
Medical and Biological Physics ,Engineering ,Health Sciences ,Sports Science and Exercise ,Biomedical Engineering ,Physical Sciences ,Clinical Research ,Osteoporosis ,Biomedical Imaging ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Aged ,Body Size ,Bone Density ,Female ,Femur Neck ,Finite Element Analysis ,Humans ,Middle Aged ,Phantoms ,Imaging ,Posture ,Reference Standards ,Tomography ,X-Ray Computed ,Quantitative computed tomography ,Hip ,Bone mineral density ,Biomechanics ,Medical and Health Sciences ,Biomedical engineering ,Sports science and exercise ,Medical and biological physics - Abstract
In multicenter studies and longitudinal studies that use two or more different quantitative computed tomography (QCT) imaging systems, anthropomorphic standardization phantoms (ASPs) are used to correct inter-scanner differences and allow pooling of data. In this study, in vivo imaging of 20 women on two imaging systems was used to evaluate inter-scanner differences in hip integral BMD (iBMD), trabecular BMD (tBMD), cortical BMD (cBMD), femoral neck yield moment (My) and yield force (Fy), and finite-element derived strength of the femur under stance (FEstance) and fall (FEfall) loading. Six different ASPs were used to derive inter-scanner correction equations. Significant (p
- Published
- 2014