1. Machine-learning based comparison of CT-perfusion maps and dual energy CT for pancreatic tumor detection
- Author
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Wolfram Stiller, Franziska Fritz, Stephan Skornitzke, Klaus H. Maier-Hein, Philipp Mayer, Michael Goetz, Christian Weber, and Marco Koell
- Subjects
Computer science ,business.industry ,Perfusion scanning ,Machine learning ,computer.software_genre ,medicine.disease ,030218 nuclear medicine & medical imaging ,Radiation exposure ,Functional imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Pancreatic tumor ,030220 oncology & carcinogenesis ,medicine ,Artificial intelligence ,Dual energy ct ,Pancreas ,business ,computer ,Perfusion - Abstract
Perfusion CT is well-suited for diagnosis of pancreatic tumors but tends to be associated with a high radiation exposure. Dual-energy CT (DECT) might be an alternative to perfusion CT, offering correlating contrasts while being acquired at lower radiation doses. While previous studies compared intensities of Dual Energy iodine maps and CT-perfusion maps, no study has assessed the combined discriminative power of all information that can be generated from an acquisition of both functional imaging methods. We therefore propose the use of a machine learning algorithm for assessing the amount of information that becomes available by the combination of multiple images. For this, we train a classifier on both imaging methods, using a new approach that allows us to train only from small regions of interests (ROIs). This makes our study comparable to other - ROI-based analysis - and still allows comparing the ability of both classifiers to discriminate between healthy and tumorous tissue. We were able to train classifiers that yield DICE scores over 80% with both imaging methods. This indicates that Dual Energy Iodine maps might be used for diagnosis of pancreatic tumors instead of Perfusion CT, although the detection rate is lower. We also present tumor risk maps that visualize possible tumorous areas in an intuitive way and can be used during diagnosis as an additional information source.
- Published
- 2016
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