1. Correlation Between High Expression of FOXA2 and Improved Overall Survival in Ovarian Cancer Patients
- Author
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Hui Shang, Peng Zhou, Yongqing Wei, Lingyun Shi, and Xuena Jiang
- Subjects
Databases, Factual ,030204 cardiovascular system & hematology ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Diagnosis ,medicine ,Cluster Analysis ,Humans ,Protein Interaction Maps ,KEGG ,Gene ,reproductive and urinary physiology ,Survival analysis ,Ovarian Neoplasms ,Regulation of gene expression ,Gene Expression Profiling ,Cancer ,General Medicine ,respiratory system ,Prognosis ,medicine.disease ,Survival Analysis ,Gene Expression Regulation, Neoplastic ,030220 oncology & carcinogenesis ,embryonic structures ,Hepatocyte Nuclear Factor 3-beta ,Database Analysis ,Cancer research ,Immunohistochemistry ,Female ,FOXA2 ,Ovarian cancer - Abstract
BACKGROUND The aim of the present work was to evaluate FOXA2 expression in ovarian cancer and to use integrated bioinformatics analysis to correlate it with patient prognosis. MATERIAL AND METHODS FOXA2 expression was evaluated in multiple cancers in The Cancer Genome Atlas database. A protein-protein interaction (PPI) network relevant to FOXA2 was constructed using the Search Tool for Retrieval of Interacting Genes/Proteins (STRIN). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed of FOXA2 and relevant genes. Correlations between overall survival (OS), disease-free survival, and FOXA2 expression were evaluated. An immunohistochemical assay (IHC) was used to test for FOXA2 protein expression in 79 ovarian cancer specimens. RESULTS FOXA2 mRNA was upregulated in colorectal, stomach, liver, and endometrial cancers. In the PPI network, 21 protein nodes and 533 edges were constructed with a local clustering coefficient of 0.698, which indicated significant PPI enrichment (P
- Published
- 2021
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