1. The Prognostic Value of Expression of the Long Noncoding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) in Patients with Solid Malignant Tumors: A Systematic Review and Meta-Analysis
- Author
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Zhaohao Huang, Bufan Xiao, Bentong Yu, Ruihao Zhou, and Jingtao Zhang
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,Malignancy ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Glioma ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,RNA, Small Nucleolar ,Cell Proliferation ,business.industry ,Cancer ,General Medicine ,Esophageal cancer ,Prognosis ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Meta-analysis ,Osteosarcoma ,RNA, Long Noncoding ,Ovarian cancer ,business ,Meta-Analysis - Abstract
BACKGROUND The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is expressed in solid malignant tumors. The aim of this systematic review and meta-analysis was to determine whether expression of the lncRNA SNHG1 was associated with prognosis in patients with malignancy. MATERIAL AND METHODS A literature review from Jan 1970 to July 2018 identified publications in the English language. Databases searched included: PubMed, OVID, Web of Science, the Cochrane Database, Embase, EBSCO, Google Scholar. Systematic review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Newcastle-Ottawa Scale (NOS) assessment tool for risk of bias was used. RESULTS Eight publications (570 patients) and eight solid tumors were identified, including osteosarcoma, colorectal cancer, hepatocellular carcinoma, non-small cell lung cancer, esophageal cancer, ovarian cancer, glioma, and gastric cancer. Meta-analysis showed that expression of the lncRNA SNHG1 was significantly correlated with reduced overall survival (OS) (HR=1.917; 95% CI, 1.58-2.31) (P
- Published
- 2018
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