1. Electroencephalographic Abnormalities in Autism Spectrum Disorder: Characteristics and Therapeutic Implications
- Author
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Luigi Vetri, Lucia Parisi, Francesco Precenzano, Claudia Santoro, Ilaria Bitetti, Giovanni Messina, Grazia Maria Giovanna Pastorino, Francesca Felicia Operto, Maria Cristina Risoleo, Valentina Lanzara, Maria Ruberto, Rosa Marotta, Precenzano F., Parisi L., Lanzara V., Vetri L., Operto F.F., Pastorino G.M.G., Ruberto M., Messina G., Risoleo M.C., Santoro C., Bitetti I., Marotta R., Precenzano, F., Parisi, L., Lanzara, V., Vetri, L., Operto, F. F., Pastorino, G. M. G., Ruberto, M., Messina, G., Risoleo, M. C., Santoro, C., Bitetti, I., and Marotta, R.
- Subjects
Male ,medicine.medical_specialty ,Medicine (General) ,Autism Spectrum Disorder ,autism spectrum disorders ,Population ,Epiphenomenon ,Dysfunctional family ,Child Behavior Disorders ,Review ,Audiology ,behavioral disciplines and activities ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,Borderline intellectual functioning ,R5-920 ,mental disorders ,medicine ,Humans ,Cognitive Dysfunction ,education ,Child ,Subclinical infection ,education.field_of_study ,Evidence-Based Medicine ,Epileptogenic abnormalitie ,business.industry ,epileptogenic abnormalities ,Electroencephalography ,General Medicine ,electroencephalogram ,medicine.disease ,Settore MED/39 - Neuropsichiatria Infantile ,030227 psychiatry ,Autism spectrum disorder ,Autism ,Anticonvulsants ,Female ,Autism spectrum disorders, Electroencephalogram, Epilepsy, Epileptogenic abnormalities, Non-epileptiform abnormalities ,business ,non-epileptiform abnormalities ,030217 neurology & neurosurgery - Abstract
A large body of literature reports the higher prevalence of epilepsy in subjects with Autism Spectrum Disorder (ASD) compared to the general population. Similarly, several studies report an increased rate of Subclinical Electroencephalographic Abnormalities (SEAs) in seizure-free patients with ASD rather than healthy controls, although with varying percentages. SEAs include both several epileptiform discharges and different non-epileptiform electroencephalographic abnormalities. They are more frequently associated with lower intellectual functioning, more serious dysfunctional behaviors, and they are often sign of severer forms of autism. However, SEAs clinical implications remain controversial, and they could represent an epiphenomenon of the neurochemical alterations of autism etiology. This paper provides an overview of the major research findings with two main purposes: to better delineate the state-of-the-art about EEG abnormalities in ASD and to find evidence for or against appropriateness of SEAs pharmacological treatment in ASD.
- Published
- 2020