Objective: To compare the results of quality monitoring after the implementation of improvement strategies in the respiratory intensive care unit (RICU)., Design: A prospective, comparative, longitudinal and interventional study was carried out., Setting: The RICU of Hospital General de México (Mexico)., Patients: All patients admitted to the RICU from March 2012 to March 2013., Interventions: An evidence-based bundle of interventions was implemented in order to reduce the ratios of three quality indicators: non-planned extubation (NPE), reintubation, and ventilator-associated pneumonia (VAP)., Variables of Interest: NPE, reintubation and VAP ratios., Results: A total of 232 patients were admitted, with a mean age of 49.5±17.8years; 119 (50.5%) were woman. The mean Simplified Acute Physiology Score (SAPS-3) was 49.8±17, and the mean Sequential Organ Failure Assessment (SOFA) score was 5.3±4.1. The mortality rate in the RICU was 38.7%. The standardized mortality ratio was 1.50 (95%CI: 1.20-1.84). An improved ratio was observed for reintubation and NPE indicators compared to the ratios of the previous 2011 cohort: 1.6% vs. 7% (P=.02) and 8.1 vs. 17 episodes per 1000 days of mechanical ventilation (P=.04), respectively. A worsened VAP ratio was observed: 18.4 vs. 15.1 episodes per 1000 days of mechanical ventilation (P=.5)., Conclusions: Quality improvement is feasible with the identification of areas of opportunity and the implementation of strategies. Nevertheless, the implementation of a bundle of preventive measures in itself does not guarantee improvements., (Copyright © 2013 Elsevier España, S.L.U. and SEMICYUC. All rights reserved.)