1. Multiorgan Toxicity from Dual Checkpoint Inhibitor Therapy, Resulting in a Complete Response-A Case Report.
- Author
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Astašauskaitė S, Kupčinskaitė-Noreikienė R, Zaborienė I, Vaičiūnienė R, Vanagas T, Pranys D, Poškienė L, and Juozaitytė E
- Subjects
- Humans, Male, Middle Aged, Colitis chemically induced, Treatment Outcome, Programmed Cell Death 1 Receptor antagonists & inhibitors, CTLA-4 Antigen antagonists & inhibitors, Immune Checkpoint Inhibitors adverse effects, Carcinoma, Renal Cell drug therapy, Kidney Neoplasms drug therapy
- Abstract
Immunotherapy treatment with checkpoint inhibitors (ICIs) has led to a breakthrough in the treatment of oncological diseases. Despite its clinical effectiveness, this treatment differs from others, such as cytotoxic chemotherapy, in that it causes immune-related adverse events. This type of toxicity can affect any organ or organ system of the body. We present a literature review and a rare clinical case from our clinical practice, in which a patient with metastatic clear cell renal carcinoma was treated with a single dose of dual checkpoint blockade (cytotoxic T-lymphocyte-4 (CTLA-4) and programmed death-1 (PD-1)) and simultaneously diagnosed with colitis, hepatitis, and nephritis. After early immunosuppressive treatment with the glucocorticoids, complete organ function recovery was achieved. The follow-up revealed a sustained complete response lasting more than a year.
- Published
- 2024
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