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Multiple therapies have been tested on the present pandemic. Convalescent plasma (CP) is being empirically applied on different trials as a possible treatment to avoid severe presentations of coronavirus disease-19. These treatments have been used before for other infectious diseases with controversial results. The study of this virus is still ongoing, and new information is being gathered daily that could upgrade the approach to get new solutions. Up to this day, vaccines are the most promising therapy to avoid infection, but no successful therapy has been found to cure the actual disease. As we present in this paper, there is controversial information on CP. Still, due to the actual global situation, the medical guild has needed to learn empirically on the road of treating the patients. Results are shown of the most relevant trials that have been made. Furthermore, we mention the trials that are not yet finished for further review.