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Condensation of iminodiacetic acid 1 with various amines i.e., cyclohexanamine, 1-(3-aminopropyl)imidazole, pyridin-2-ylmethanamine, pyridin-3-ylmethanamine, pyridin-4-ylmethanamine, 2-morpholinoethanamine, thiophen-2-ylmethanamine, 2-(thiophen-2-yl)ethanamine, furan-2-ylmethanamine, 2-(pyrrolidin-1-yl)ethanamine, and 1-(3-aminopropyl) pyrrolidin-2-one 2a- k under microwave irradiation gave the corresponding piperazine-2,6-dione derivatives 3a- k in quantitative yields. Piperazine-2,6-dione derivatives 3a- k on condensation with 1 H-indole-2-carboxylic acid under microwave irradiation gave the corresponding 4-(1 H-indole-2-carbonyl)piperazine-2,6-dione derivatives 4a- k in quantitative yields. All the synthesized compounds ( 3a- k & 4a- k) were purified by crystallization and characterized by spectroscopic means. On screening at a concentration of 10 μM, compounds 3k, 4e, 4i breast (T47D), 4j lung (NCI H-522), 3i colon (HCT-15), 4e ovary (PA-1), and 4g liver (HepG-2) exhibited good anticancer activity. [ABSTRACT FROM AUTHOR]

9,10-Dihydroanthracene-9,10- α, β-succinimide derivatives 4a- e and bis-succinimide derivatives 6a- e have been synthesized by grinding 9,10-dihydroanthracene-9,10- α, β-succinic anhydride 2 with various mono 3a- e and diamines 5a- e in quantitative yields. All the target compounds were fully characterized by spectrometric and spectroscopic means. Compounds 4a- e, 6a- e and recently reported compounds 4f- p were screened for anti-inflammatory and for cytotoxicity against five human cancer cell lines: T47D, NCI H-522, HCT-15, PA1, and HepG-2. Compounds 4e, 4i, 4j, and 4p exhibited good anti-inflammatory activity and compounds with interesting cytotoxic profile were 4c, 6e (T47D); 4e, 4o (NCI H-522); 4n (HCT-15); 4e, 4h, 4o (PA1); and 4a, 4e, 4f, 4i, 4o (HepG-2). [ABSTRACT FROM AUTHOR]