Search

Your search keyword '"Chen Dong"' showing total 48 results
Start Over Author "Chen Dong" Journal medicine
48 results on '"Chen Dong"'

1. The Effect of Preoperative Apolipoprotein A-I on the Prognosis of Surgical Renal Cell Carcinoma

Author

Guo, Shengjie, He, Xiaobo, Chen, Qian, Yang, Guangwei, Yao, Kai, Dong, Pei, Ye, Yunlin, Chen, Dong, Zhang, Zhiling, Qin, Zike, Liu, Zhuowei, Li, Zaishang, Xue, Yunfei, Zhang, Meng, Liu, Ruiwu, Zhou, Fangjian, and Han, Hui

Subjects
Atherosclerosis, Clinical Research, Kidney Disease, Cancer, Adult, Aged, Apolipoprotein A-I, Carcinoma, Renal Cell, Cohort Studies, Female, Follow-Up Studies, Humans, Kidney Neoplasms, Lipids, Male, Middle Aged, Neoplasm Staging, Prognosis, Reference Values, Retrospective Studies, Statistics as Topic, Survival Rate, Clinical Sciences, Arthritis & Rheumatology
Abstract

The prognostic value of serum lipid-profile in renal cell cancer (RCC) remains unknown. The purpose of the study is to explore the association between the serum lipid-profile and RCC patients.The levels of preoperative serum lipid-profile (including cholesterol, triglycerides, high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], apolipoprotein A-I [ApoA-I], and apolipoprotein B [ApoB]) were retrospectively performed in 786 patients with RCC. The cutoff values of the lipids were determined by the receiver-operating characteristic (ROC) curve analysis. Univariate and multivariate Cox regression analyses were performed to investigate the prognostic value of serum lipids in RCC.Combined ROC analysis and univariate and multivariate Cox regression analyses, for overall survival (OS), revealed patients with low ApoA-I (

Published
2016

26. Clinical and histopathologic features of sodium taurocholate cotransporting polypeptide deficiency in pediatric patients

Author

Zai-sheng Cai, Ben-Ping Zhang, Sainan Shu, Dao Wen Wang, Zhi-Hua Huang, Chao Zhang, Hui Xu, Chen Dong, Xiao-ping Luo, and Hong Wang

Subjects
sodium taurocholate cotransporting polypeptide, Gene mutation, Pediatrics, Gastroenterology, Child Development, 0302 clinical medicine, Liver Function Tests, 030212 general & internal medicine, Membrane Glycoproteins, Symporters, Bile acid, biology, medicine.diagnostic_test, Liver Diseases, General Medicine, Gallstones, Jaundice, Liver, Child, Preschool, 030220 oncology & carcinogenesis, medicine.symptom, Research Article, Image-Guided Biopsy, China, medicine.medical_specialty, hyperbilirubinemia, medicine.drug_class, Observational Study, Organic Anion Transporters, Sodium-Dependent, digestive system, Asymptomatic, Bile Acids and Salts, 03 medical and health sciences, Internal medicine, medicine, Humans, Genetic Testing, Retrospective Studies, SLC10A1, business.industry, Infant, Retrospective cohort study, medicine.disease, Mutation, biology.protein, business, Liver function tests, hyperbileacidemia
Abstract

Until now, the recognition of sodium taurocholate cotransporting polypeptide (NTCP) deficiency has been mainly based on sporadic case reports. It was previously believed to be mildly symptomatic and resulting in mild liver dysfunction. However, to our knowledge, there have been no reports about the histopathologic and ultrastructural pathologic characteristics of the disease. The aim of the study was to analyze the clinical, histopathologic and ultrastructural pathologic characteristics of NTCP deficiency in 13 pediatric patients. From August 2012 to October 2018, this retrospective study conducted in the Department of Pediatrics of Tongji Hospital, China analyzed the data of 13 NTCP deficient patients with an SLC10A1 gene mutation. Except for NTCP deficiency, no other liver diseases were present in the patients, which was determined by both a genetic testing panel for jaundice and by reviewing medical records. The laboratory results, imaging, histopathologic, and ultrastructural pathologic information were recorded for analysis. The serum level of total bile acid was high in all 13 patients. All patients had adequate growth and development. Eight of the patients (8/13) presented with visible jaundice and 12 (12/13) were found to have hyperbilirubinemia. A needle liver biopsy was performed in 11 cases, which revealed slightly chronic inflammation in all 11 patients. One of the patients (1/13) was found to be suffering from gallstones. The data showed that although NTCP deficiency was often asymptomatic, some of the patients showed obvious clinical expressions, such as jaundice. Among the 13 pediatric patients with NTCP deficiency, both the biochemical and histopathologic features were similar to those of mild hepatocellular jaundice. In addition, it was determined that the clinical features in the patient with gallstones may have been caused by NTCP deficiency.

Published
2019

33. Effect of bispectral index-guided anesthesia on consumption of anesthetics and early postoperative cognitive dysfunction after liver transplantation

Author

Ping Chi, Ying-Hao Cao, Yan-Xing Zhao, and Xi-Chen Dong

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Observational Study, S100 Calcium Binding Protein beta Subunit, Neuropsychological Tests, optimizing intraoperative management, Liver transplantation, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, S100β protein, 030202 anesthesiology, Humans, Medicine, Cognitive Dysfunction, Propofol, liver transplantation, business.industry, postoperative cognitive dysfunction, General Medicine, Middle Aged, medicine.disease, neuron-specific enolase, Surgery, Phosphopyruvate Hydratase, bispectral index-guided anesthesia, Bispectral index, Anesthesia, Anesthetic, Anesthesia, Intravenous, Female, Observational study, business, Postoperative cognitive dysfunction, Anesthetics, Intravenous, 030217 neurology & neurosurgery, Research Article, medicine.drug
Abstract

The objective of this study was to summarize the incidence of postoperative cognitive dysfunction (POCD) after 7days following liver transplantation (LT), and to evaluate the effectiveness of bispectral index (BIS) guided anesthetic intervention in reducing POCD. Additional serum concentrations of S100β and neuron-specific enolase (NSE) were detected during surgery to determine whether they were reliable predictors of POCD. Patients who underwent LT at Beijing YouAn Hospital Affiliated to Capital University of Medical Science from January 2014 to December 2015 were enrolled. BIS monitor was needed during surgery. Patients who underwent LT without BIS monitoring during August 2012 to December 2014 served as historical controls. A battery of 5 neuropsychological tests were performed and scored preoperatively and 7days after surgery. POCD was diagnosed by the method of one standard deviation (SD). The blood samples of BIS group were collected at 5 time points: just before induction of general anesthesia (T0), 60 minutes after skin incision (T1), 30 minutes after the start of the anhepatic phase (T2), 15 minutes after reperfusion of the new liver (T3), and at 24 hours after surgery (T4). A total of 33 patients were included in BIS group, and 27 in the control group. Mean arterial pressure was different between 2 groups at 30 minutes after the start of the anhepatic phase (P = .032). The dose of propofol using at anhepatic phase 30 min and new liver 15 min was lower in the BIS group than control group (0.042 ± 0.021 vs. 0.069 ± 0.030, P .05). But at 24 hours after surgery, NSE concentrations were still high of patients with POCD (8.14 ± 3.25 vs. 4.81 ± 3.50, P = .035). BIS-guided anesthesia can reduce consumption of propofol during anhepatic and new liver phase. Patients in BIS group seem to have a mild lower incidence of POCD compared to controls, but no statistical significant. The influence of BIS-guided anesthesia on POCD needs to be further confirmed by large-scale clinical study. S100β protein and NSE are well correlative with neural injury, but NSE is more suitable for assessment of incidence of postoperative cognitive deficits after surgery.

Published
2017

40. Sitagliptin After Ischemic Stroke in Type 2 Diabetic Patients

Author

Chen, Dong-Yi, primary, Wang, Szu-Heng, additional, Mao, Chun-Tai, additional, Tsai, Ming-Lung, additional, Lin, Yu-Sheng, additional, Su, Feng-Chieh, additional, Chou, Chung-Chuan, additional, Wen, Ming-Shien, additional, Wang, Chun-Chieh, additional, Hsieh, I-Chang, additional, Hung, Kuo-Chun, additional, Cherng, Wen-Jin, additional, and Chen, Tien-Hsing, additional

Published
2015
Full Text
View/download PDF

46. Comparisons of Clinical Outcomes and Prognoses in Patients With Gastroesophageal Junction Adenocarcinoma, by Transthoracic and Transabdominal Hiatal Approaches: A Teaching Hospital Retrospective Cohort Study.

Author

Jinzhe Zhou, Hao Wang, Zhaojian Niu, Dong Chen, Dongsheng Wang, Liang Lv, Yu Li, Jian Zhang, Shougen Cao, Yi Shen, Yanbing Zhou, Zhou, Jinzhe, Wang, Hao, Niu, Zhaojian, Chen, Dong, Wang, Dongsheng, Lv, Liang, Li, Yu, Zhang, Jian, and Cao, Shougen

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results