1. CDC20 overexpression leads to poor prognosis in solid tumors: A system review and meta-analysis
- Author
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Liang Zhang, Zhengjie Huang, Borong Chen, Qi Luo, Zhipeng Zhu, Gang Liu, Disheng Xiong, Guoxing Xu, Shengjie Wang, and Junjie Zeng
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Poor prognosis ,Multivariate analysis ,Cdc20 Proteins ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Neoplasms ,medicine ,Biomarkers, Tumor ,Humans ,Proportional Hazards Models ,Univariate analysis ,Proportional hazards model ,business.industry ,Hazard ratio ,Univariate ,CDC20 ,General Medicine ,Prognosis ,Confidence interval ,meta-analysis ,030104 developmental biology ,030220 oncology & carcinogenesis ,Meta-analysis ,Multivariate Analysis ,solid tumor ,business ,Systematic Review and Meta-Analysis ,Research Article - Abstract
Background: A plenty of previous researches have reported the prognostic value of CDC20 (Cell Division Cycle Protein 20) in solid tumors. Nevertheless, these researches were restricted by the small sample databases and the results were not strongly consistent among them. Methods: We comprehensively searched these relevant studies by PubMed, Web of Science, and EMBASE, in which publications before March 2017 were included. Pooled HR values for OS were cumulatively pooled and quantitatively analyzed in the meta-analysis. Results: Hence we composed a meta-analysis based on 8 studies with 1856 patients in order to assess the potential relationship between CDC20 overexpression and OS (overall survival) in human solid tumors. There were a total of 8 studies (n = 1856) assessed in the meta-analysis. What suggested in both univariate and multivariate analysis for survival is that high level of CDC20 expression apparently pointed to poor prognosis. In the univariate analysis, the combined hazard ratio (HR) for OS was 1.75 (95% confidence interval [CI]: 1.07–2.86, P = .03). The pooled HR of multivariate analysis for OS was 2.48 (95% confidence interval [CI]: 2.10–2.94, P
- Published
- 2018