1. What is the appropriate duration of adjuvant imatinib mesylate treatment for primary gastrointestinal stromal tumors classified according to the strict definition of tumor rupture?
- Author
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Ju-Li Lin, Chao-Hui Zheng, Qi-Yue Chen, Jia-Bin Wang, Chang-Ming Huang, Jian-Wei Xie, Ru-Hong Tu, Yun Dai, Long-Long Cao, Jun Lu, Ping Li, Jian-Xian Lin, Hua-Long Zheng, Mi Lin, and Ze-Ning Huang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Stromal cell ,Gastrointestinal Stromal Tumors ,medicine.medical_treatment ,Observational Study ,Antineoplastic Agents ,Gastroenterology ,Drug Administration Schedule ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,tumor rupture ,imatinib mesylate ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Young adult ,Survival rate ,Aged ,Retrospective Studies ,Aged, 80 and over ,Chemotherapy ,Rupture, Spontaneous ,GiST ,business.industry ,Retrospective cohort study ,General Medicine ,Middle Aged ,Prognosis ,digestive system diseases ,Survival Rate ,Treatment Outcome ,Imatinib mesylate ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Female ,business ,Adjuvant ,Follow-Up Studies ,Research Article ,GIST - Abstract
Supplemental Digital Content is available in the text, In gastrointestinal stromal tumors (GISTs), rupture is a high-risk feature; however, “tumor rupture” is inconsistently defined, and its prognostic value remains controversial. Six hundred ninety-one patients undergoing surgery for primary nonmetastatic GISTs from 2003 to 2015 at our institution were enrolled. The strict definitions of “tumor rupture” according to the Kinki GIST Study Group (KGSG) were used. The median follow-up time was 64 months. The 5-year recurrence-free survival (RFS) and overall survival (OS) rates in the entire group were 79.3% and 84.1%, respectively. According to the KGSG's definition, tumor rupture occurred only in 24 (3.5%) of 691 patients. For all 691 patients, multivariable analysis showed that tumor rupture, according to KGSG's definition, is one of the independently prognostic factors for both RFS and OS. Twenty-four patients with tumor rupture were further analyzed. Receiving IM for more than 3 years was significantly associated with improved RFS and OS in GISTs patients with tumor rupture. Tumor rupture according to KGSG's definition was an independent predictive factor associated with GIST patient prognosis. More importantly, for GISTs with tumor rupture according to the KGSG's strict definition, receiving IM treatment for ≥3 years should be considered.
- Published
- 2019