1. Reduced NM23 Protein Level Correlates With Worse Clinicopathologic Features in Colorectal Cancers
- Author
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Yang, Tian, Chen, Bo-Zan, Li, Dan-Feng, Wang, Huai-Ming, Lin, Xiao-Sheng, Wei, Hong-Fa, and Zeng, Yong-Ming
- Subjects
Survival Rate ,Lymphatic Metastasis ,Humans ,NM23 Nucleoside Diphosphate Kinases ,Neoplasm Grading ,Colorectal Neoplasms ,Systematic Review and Meta-Analysis ,Research Article ,Neoplasm Staging - Abstract
The clinical value of a prominent metastasis suppressor, nonmetastatic protein 23 (NM23), remains controversial. In this study, we examined the correlation between NM23 protein levels and the clinicopathologic features of colorectal cancers (CRC), and assessed the overall prognostic value of NM23 for CRC. Embase, PubMed, Web of Science, and other scientific literature databases were exhaustively searched to identify relevant studies published prior to June 31, 2015. The methodological qualities of selected studies were scored based on the critical appraisal skills program (CASP) criteria, as independently assessed by 2 reviewers. NM23 protein levels in tumor tissues of CRC patients were examined in relation to Dukes stage, differentiation grade, T-stage, lymph node metastasis status, and overall survival (OS). STATA software version 12.0 (Stata Corp, College Station, TX) was used for statistical analysis of data pooled from selected studies. Nineteen cohort studies met the inclusion criteria for present study and contained a combined total of 2148 study subjects. Pooled odd ratios (ORs) for NM23 expression revealed that reduced NM23 protein levels in CRC tumor tissues correlated with Dukes stage C and D (OR = 1.89, 95% CI: 1.06–3.39, P = 0.032), poor differentiation grades (OR = 1.41, 95% CI: 1.03–1.94, P = 0.032), and positive lymph node metastasis status (OR = 3.21, 95% CI: 1.95–5.29, P
- Published
- 2016