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Start Over Author "Liu, Song" Journal medicine
46 results on '"Liu, Song"'

9. Clinical application of gelatin sponge microparticles-transcatheter arterial chemoembolization combined with synchronous antigen-presenting dendritic cell sequential reinfusion for treatment of advanced large liver cancer

Author

Zhao, Guang Sheng, primary, Liu, Song, additional, Liu, Ying, additional, Li, Chuang, additional, Wang, Ruo Yu, additional, Bian, Jie, additional, Zhu, Rui Ping, additional, Zhou, Jun, additional, and Zhang, Yue Wei, additional

Published
2022
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12. Transcatheter Arterial Chemoembolization With Gelatin Sponge Microparticles Treated for BCLC Stage B Hepatocellular Carcinoma

Author

Kamran, Asad Ullah, Liu, Ying, Li, Feng E., Liu, Song, Wu, Jian Lin, and Zhang, Yue Wei

Subjects
Adult, Carcinoma, Hepatocellular, Organoplatinum Compounds, Liver Neoplasms, Observational Study, Antineoplastic Agents, Middle Aged, Survival Analysis, Porifera, Injections, Intra-Arterial, Animals, Gelatin, Humans, Female, Chemoembolization, Therapeutic, Cyclobutanes, Research Article, Aged, Neoplasm Staging, Retrospective Studies
Abstract

Gelatin sponge particles are commonly used in the conventional transarterial chemoembolization (c-TACE) as an adjuvant embolizing agent for hepatocellular carcinoma (HCC). However, there are few reports regarding the clinical applications of gelatin sponge microparticles (GSMs) as a main embolizing agent in the treatment of HCC. This retrospective study aim to evaluate the efficacy and safety of patients with Barcelona Clinic Liver Cancer (BCLC) stage B HCC treated with intra-arterial injection of 350 to 560 μm GSMs mixed with anticancer agents. Twenty-four patients with unresectable BCLC stage B HCC without any prior treatment underwent transarterial chemoembolization with gelatin sponge microparticles (GSMs-TACE) of diameter 350 to 560 μm mixed with lobaplatin. The mixture was injected into tumor-feeding arteries until the sluggish flow in selective artery. Safety was measured by assessing complication rate, and efficacy was reflected by assessing response to mRECIST therapy and overall survival. The survival rate was calculated using the Kaplan–Meier method. All 24 BCLC stage B HCC patients showed good tolerance to the procedure. The mean follow-up period was 27 months and mean number of TACE treatments per patient was 3.7 sessions (range 1–10) during the follow-up period. Postprocedure complications were mild and treated by symptomatic treatment. Six months and 1 year overall survival rates were 100% and 87.5%, respectively. Overall median survival time was 25 months (95%CI: 21.06–28.95 months). GSMs-TACE is a safe and effective method for BCLC stage B HCC patients.

Published
2015

13. Time-course of Changes in Activation Among Facial Nerve Injury

Author

Xiao, Fu-Long, Gao, Pei-Yi, Sui, Bin-Bin, Wan, Hong, Lin, Yan, Xue, Jing, Zhou, Jian, Qian, Tian-Yi, Wang, Shiwei, Li, Dezhi, and Liu, Song

Subjects
Adult, Facial Nerve Injuries, Male, Time Factors, Functional Neuroimaging, Observational Study, Neuroma, Acoustic, Middle Aged, Adaptation, Physiological, Magnetic Resonance Imaging, Neurosurgical Procedures, Case-Control Studies, Humans, Female, Sensorimotor Cortex, Research Article
Abstract

Patients suffering different intervals of facial nerve injury were investigated by functional magnetic resonance imaging to study changes in activation within cortex. Forty-five patients were divided into 3 groups based on intervals of facial nerve injury. Another 16 age and sex-matched healthy participants were included as a control group. Patients and healthy participants underwent task functional magnetic resonance imaging (eye blinking and lip pursing) examination. Functional reorganization after facial nerve injury is dynamic and time-dependent. Correlation between activation in sensorimotor area and intervals of facial nerve injury was significant, with a Pearson correlation coefficient of −0.951 (P

Published
2015

16. An Elevated Percentage of Reticulated Platelet Is Associated With Increased Mortality in Septic Shock Patients

Author

Wu, Qin, primary, Ren, Jianan, additional, Hu, Dong, additional, Jiang, Pengjun, additional, Li, Guanwei, additional, Anjum, Nadeem, additional, Wang, Gefei, additional, Gu, Guosheng, additional, Chen, Jun, additional, Wu, Xiuwen, additional, Liu, Song, additional, Li, Yuan, additional, Zhao, Yunzhao, additional, and Li, Jieshou, additional

Published
2015
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46. Pharmacological effect and mechanism of orlistat in anti-tumor therapy: A review.

Author

Hao X, Zhu X, Tian H, Lai G, Zhang W, Zhou H, and Liu S

Subjects
Humans, Orlistat therapeutic use, Drug Repositioning, Glycolysis, Obesity complications, Obesity drug therapy, Apoptosis
Abstract

Research has demonstrated that obesity is an important risk factor for cancer progression. Orlistat is a lipase inhibitor with promising therapeutic effects on obesity. In addition to being regarded as a slimming drug, a growing number of studies in recent years have suggested that orlistat has anti-tumor activities, while the underlying mechanism is still not well elucidated. This paper reviewed recent pharmacological effects and mechanisms of orlistat against tumors and found that orlistat can target cancer cells through activation or suppression of multiple signaling pathways. It can induce tumor cells apoptosis or death, interfere with tumor cells' cycles controlling, suppress fatty acid synthase activity, increase ferroptosis, inhibit tumor angiogenesis, and improve tumor cells glycolytic. Thus, this review may shed new light on anti-tumor mechanism and drug repurposing of orlistat, and anti-tumor drug development., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2023
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