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Serious bacterial infection (SBI) is a major cause of morbidity and mortality in children. Distinguishing SBI from self-limiting viral infections is a very important task in the emergency department (ED), especially in the children with fever without source (FWS). The aim of this study was to analyze whether parents’ statements about clinical manifestations, which were categorized according to grades, are related to the actual diagnosis of SBI in children with FWS. Retrospective analysis was conducted using prospectively acquired cohort data for all febrile children in the pediatric ED of Seoul National University Hospital from August 2016 to August 2017. The association of clinical manifestations and SBI was the main outcome of this study. The SBIs included diagnoses such as bacteremia, bacterial meningitis, urinary tract infection, and pneumonia. Clinical manifestations including activity, urination, and feeding were categorized into 3 or 4 grades according to the parents’ statements. The linear-by-linear association test was used to examine linear associations between the severity of clinical manifestations and SBI. Receiver operating characteristic curves for clinical manifestations were constructed for patients with SBI. Area under the curve (AUC) statistics and 95% confidence intervals (CIs) were obtained to evaluate the predictive performance of clinical manifestations. There was no linear association between SBI and non-SBI when compared by severity of the clinical manifestations, such as duration of fever (P = .299), activity (P = .781), feeding (P = .161), and urination (P = .834). The AUC was 0.54 (95% CI 0.41–0.67) for duration of fever, 0.52 for activity (95% CI 0.40–0.64), 0.42 for feeding (95% CI 0.32–0.53), and 0.51 for urination (95% CI 0.39–0.62). There was no evidence that the test performance of the clinical manifestations is valid for predicting SBIs, even considering the severity of manifestations. For optimal evaluation of the children with FWS, more comprehensive approach including laboratory tests, are needed.

The primary objective was to evaluate the characteristics of adults (≥18 years old) with chronic pediatric disorders (transition patients) who visited the pediatric emergency department (PED). The secondary objective was to determine the associated factors for their admission. This study was a retrospective chart review of transition patients seen at a large, urban PED in Korea from 2010 to 2015. Epidemiologic and clinical data were used to identify the characteristics of transition patients compared with those of pediatric patients in the PED. A multivariable logistic regression model was used to calculate odds ratios (ORs) for the factors associated with hospitalization. Transition patients accounted for 2776 (2.4%) of the total encounters. A total of 463 (38.9%) of the transition patients had >1 visit. Congenital heart disease was the most common (23.2%) chronic pediatric disorder. Most encounters (94.5%) were related to an underlying disorder, and 34.4% of the encounters required consultations with other pediatric subspecialties. Diagnostic procedures were performed in 90.1% of the encounters. Transition patients were hospitalized more than pediatric patients (35.3% vs 15.3%; P