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Your search keyword '"Zhou, Qian"' showing total 19 results
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19 results on '"Zhou, Qian"'

11. Efficacy and safety of remimazolam in procedural sedation and analgesia

Author

Jiejuan Chen, Jing Quan, Zou Xiaohua, Shi Jing, Minhuan Shen, Wang Feng, and Zhou Qian

Subjects
medicine.medical_specialty, medicine.medical_treatment, Sedation, Conscious Sedation, Placebo, law.invention, Benzodiazepines, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Study Protocol Systematic Review, Humans, Hypnotics and Sedatives, Medicine, 030212 general & internal medicine, endoscopy, business.industry, remimazolam, General Medicine, Publication bias, efficacy and safety, meta-analysis, midazolam, Strictly standardized mean difference, 030220 oncology & carcinogenesis, Meta-analysis, Procedural sedation and analgesia, Emergency medicine, Analgesia, medicine.symptom, business, Remimazolam, Research Article
Abstract

Background: Remimazolam is a newly developed benzodiazepine as an alternative of conventional sedatives in the procedure of anesthesia. For the purpose of evaluating the efficacy and safety of remimazolam sedation during an endoscopy, we will perform a systematic review and meta-analysis of randomized controlled trials that compared remimazolam with midazolam and/or placebo. Methods: We will search PubMed, Embase, Web of Science, and the Cochrane Controlled Register of Trials (CENTRAL) from inception to December 2019 for randomized controlled trials that investigated efficacy and safety of remimazolam during an endoscopy. The job will be performed without language restriction. Experimental groups will include the interventions of remimazolam, while control groups will involve midazolam, placebo, or no controls. The primary outcome will be the onset time, followed by the secondary outcomes of the recovery time, the incidence of hypotension, the incidence of hypoxia and the incidence of bradycardia. Relative ratio or standardized mean difference will be used to measure the effect size of remimazolam. We will use I2 statistics to assess the between-study heterogeneity in each meta-analysis, Eager's test to detect publication bias. Results: The results of this study will be published in a peer-reviewed journal. Ethics and dissemination: There is no need for ethical approval because all data used in this meta-analysis have been published. In addition, all data will be analyzed anonymously during the review process. Protocol registration number: CRD42020170745.

Published
2020
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19. Latent class analysis of healthcare workers' knowledge, attitudes, and practice levels, and risk factors regarding associated with occupational exposure to antineoplastic drugs: A multicenter cross-sectional study.

Author

Cheng J, Yuan M, Zhang S, Xiao Q, Zhou Q, and Huang X

Subjects
Humans, Cross-Sectional Studies, Female, Male, Adult, Risk Factors, China, Surveys and Questionnaires, Middle Aged, Attitude of Health Personnel, Occupational Exposure adverse effects, Occupational Exposure statistics & numerical data, Occupational Exposure prevention & control, Health Knowledge, Attitudes, Practice, Antineoplastic Agents adverse effects, Health Personnel statistics & numerical data, Health Personnel psychology, Latent Class Analysis
Abstract

The study investigated the health care workers' knowledge, attitudes, and practice levels regarding occupational protection against antineoplastic drugs (ADs) via analysis of latent classes and their influencing factors. A convenience sampling method was used to select healthcare workers from 7 hospitals in southern China between April and August 2023. A questionnaire based on literature analysis, brainstorming, and Delphi method was used to investigate the knowledge, practice, and attitudes of healthcare workers exposed to ADs for appropriate occupational protection intervention, followed by latent class analysis. The factors influencing latent classes were identified via single-factor analysis and multiple logistic regression. A total of 322 healthcare workers from departments using ADs were surveyed. The knowledge score associated with occupational protection against ADs was 31.95 ± 7.38. The attitude score was 21.08 ± 2.729, while the practice score was 36.54 ± 9.485. The overall score was 89.57 ± 15.497. The healthcare workers were divided into 4 latent classes based on their knowledge, attitude, and practice associated with occupational protection measures against ADs. Healthcare workers in the 4 categories showed significance differences based on professional title, marital status, educational background, and frequency of exposure to ADs (P < .05). The knowledge, attitude, and practice levels of healthcare workers engaged in ADs at work can be divided into 4 latent classes. Despite their increased awareness of the hazards associated with ADs and their attitudes toward protection, the healthcare workers displayed poor knowledge and implementation of occupational protection measures., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2024
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