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Start Over Author "Lobanova EA" Journal meditsinskaia radiologiia
2 results on '"Lobanova EA"'

1. [Coordinated platinum compounds in experimental and clinical oncology].

Author

Lobanova EA, Kozlova MD, Singin AS, and Serebriakov NG

Subjects
Animals, Chemical Phenomena, Chemistry, Cisplatin metabolism, Cisplatin therapeutic use, Drug Evaluation, Humans, Kinetics, Leukemia, Experimental drug therapy, Leukemia, Experimental metabolism, Male, Mice, Neoplasms metabolism, Neoplasms, Experimental drug therapy, Neoplasms, Experimental metabolism, Platinum metabolism, Testicular Neoplasms drug therapy, Testicular Neoplasms metabolism, Neoplasms drug therapy, Platinum therapeutic use
Published
1984

2. [Pharmacokinetics of the antitumor drug oxoplatinum labeled with 191Pt].

Author

Lobanova EA

Subjects
Animals, Cisplatin blood, Cisplatin metabolism, Half-Life, Mice, Mice, Inbred C57BL, Neoplasm Transplantation, Tissue Distribution, Antineoplastic Agents metabolism, Cisplatin analogs & derivatives, Melanoma metabolism
Abstract

A pharmacokinetic study of the antitumor drug oxoplatinum labeled with 191Pt when administered to control mice and mice with B-16 melanoma have shown that distribution of the drug in organs and tissues in both groups of animals is nonuniform. The drug is more tropic to the kidneys, liver, spleen, adrenals, thymus, skin and tumor. Correlation was established between the values of the coefficient ratios of differential accumulation (CDA) of the organ/blood in the final and initial periods of observation and the period of the drug half-life in the organs. The higher the CDA of the organ/blood the longer the period of the drug half-life. The excretion of the drug from the blood and most other organs is described by a bioexponential curve.

Published
1985

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