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Start Over Author "Viacheslav V. Trush" Journal mendeleev communications
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1. Polycarboxylic fullerene derivatives as protein tyrosine phosphatase inhibitors

Author

Viacheslav V. Trush, Pavel A. Troshin, I.I. Voronov, Alexander S. Peregudov, Andriy I. Vovk, Vsevolod Yu. Tanchuk, and Oleksandr L. Kobzar

Subjects
chemistry.chemical_classification, Fullerene derivatives, Fullerene, Enzyme, Chemistry, Stereochemistry, General Chemistry, Protein tyrosine phosphatase, Selectivity
Abstract

The study of the inhibition of human protein tyrosine phosphatases by water-soluble [60]fullerene derivatives bearing five organic addends loaded with carboxylic groups demonstrated that a fullerene core is responsible for interactions with the enzymes while organic addends play a minor role modifying the selectivity of the inhibition.

Published
2015

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