1. Change of histochemical and electrophysiological values of rabbit retina due to the antihypoxant sodium hydroxybutyrate.
- Author
-
Zaretskaya RB, Trutneva KV, Ostrovskaya RU, Markin VA, Zueva MV, and Suprun AV
- Subjects
- Animals, Electrophysiology, Electroretinography, Glucosephosphate Dehydrogenase metabolism, Glutamate Dehydrogenase metabolism, Isocitrate Dehydrogenase metabolism, L-Lactate Dehydrogenase metabolism, Male, NADH Dehydrogenase metabolism, Rabbits, Rats, Retina enzymology, Retina physiology, Succinate Dehydrogenase metabolism, Hydroxybutyrates pharmacology, Retina drug effects, Sodium Oxybate pharmacology
- Abstract
This paper presents the results of an electrophysiologic and histochemical study on the effect of sodium hydroxybutyrate applied perorally as 5% syrup for 20 days on the rabbit retina. It was found with statistical significance that in response to the drug the amplitudes of "a" and "b" waves of the electroretinogram increased considerably and the activation of some dehydrogenases, glucose-6-phosphatedehydrogenase and lactatedehydrogenase in particular took place; this was most pronounced in the ganglion and in the inner nuclear layers of the retina. The results of the study show that a prolonged peroral application of 5% sodium hydroxybutyrate syrup might be an expeditious way to activate energy processes in the retina.
- Published
- 1983