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Your search keyword '"M., Mazzocchi"' showing total 4 results
Start Over Author "M., Mazzocchi" Journal methods and findings in experimental and clinical pharmacology
4 results on '"M., Mazzocchi"'

2. Bile flow impairment of ventro-medial hypothalamus lesioned obese rats

Author

C, Di Padova, P, Rovagnati, F, Uggeri, M, Mazzocchi, and A, Pecile

Subjects
Bile Acids and Salts, Hypothalamus, Animals, Bile, Female, Obesity, Lipid Metabolism, Rats
Abstract

Cholesterol supersaturation of bile has been reported in human obesity. Since electrolytic lesions placed in the ventro-medial hypothalamus induce hyperphagia and obesity in the rat, bile flow and lipid composition have been studied two months after the induction of such stereotaxic lesions in a group of ten animals and in their sham-operated controls. Bile flow was significantly lower in obese rats than in controls. The bile flow reduction was attributed to a decrease of the bile acid independent fraction, since no variation in bile acid excretion rate and in bile to plasma ratio of [14C] erythritol was seen between the two groups. Whereas plasma cholesterol and triglycerides were higher in ventro-medial hypothalamus lesioned rats, biliary cholesterol and phospholipid excretion rates were similar in the two groups. These data indicate that stereotaxic lesions of ventro-medial hypothalamus in the rat significantly reduce bile flow, suggesting a correlation between active sodium transport at canalicular level and neuroendocrine hypothalamic function, but fail to induce qualitative alterations of bile lipid composition.

Published
1981

3. Bile flow impairment of ventro-medial hypothalamus lesioned obese rats.

Author

Di Padova C, Rovagnati P, Uggeri F, Mazzocchi M, and Pecile A

Subjects
Animals, Bile Acids and Salts metabolism, Female, Lipid Metabolism, Rats, Bile metabolism, Hypothalamus physiopathology, Obesity physiopathology
Abstract

Cholesterol supersaturation of bile has been reported in human obesity. Since electrolytic lesions placed in the ventro-medial hypothalamus induce hyperphagia and obesity in the rat, bile flow and lipid composition have been studied two months after the induction of such stereotaxic lesions in a group of ten animals and in their sham-operated controls. Bile flow was significantly lower in obese rats than in controls. The bile flow reduction was attributed to a decrease of the bile acid independent fraction, since no variation in bile acid excretion rate and in bile to plasma ratio of [14C] erythritol was seen between the two groups. Whereas plasma cholesterol and triglycerides were higher in ventro-medial hypothalamus lesioned rats, biliary cholesterol and phospholipid excretion rates were similar in the two groups. These data indicate that stereotaxic lesions of ventro-medial hypothalamus in the rat significantly reduce bile flow, suggesting a correlation between active sodium transport at canalicular level and neuroendocrine hypothalamic function, but fail to induce qualitative alterations of bile lipid composition.

Published
1981

4. Ursodeoxycholic acid and liver microsomal mixed function oxidase system in man.

Author

Di Padova C, Tritapepe R, Marabini L, Di Padova F, Rovagnati P, and Mazzocchi M

Subjects
Adult, Cholelithiasis metabolism, Female, Humans, Male, Microsomes, Liver metabolism, Middle Aged, Ursodeoxycholic Acid therapeutic use, Cholelithiasis drug therapy, Deoxycholic Acid analogs & derivatives, Microsomes, Liver drug effects, Mixed Function Oxygenases metabolism, Oxidoreductases metabolism, Ursodeoxycholic Acid adverse effects
Published
1981

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