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Your search keyword '"Hisaeda, Hajime"' showing total 7 results
Start Over Author "Hisaeda, Hajime" Journal microbes and infection
7 results on '"Hisaeda, Hajime"'

2. The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1

Author

Ishii, Kazunari, primary, Hisaeda, Hajime, additional, Duan, Xuefeng, additional, Imai, Takashi, additional, Sakai, Tohru, additional, Fehling, Hans Jörg, additional, Murata, Shigeo, additional, Chiba, Tomoki, additional, Tanaka, Keiji, additional, Hamano, Shinjiro, additional, Sano, Miyuki, additional, Yano, Akihiko, additional, and Himeno, Kunisuke, additional

Published
2006
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3. Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages

Author

Nakano, Yoko, primary, Hisaeda, Hajime, additional, Sakai, Tohru, additional, Ishikawa, Hiroyuki, additional, Zhang, Manxin, additional, Maekawa, Yoichi, additional, Zhang, Tianqian, additional, Takashima, Miwa, additional, Nishitani, Masaaki, additional, Good, Robert A., additional, and Himeno, Kunisuke, additional

Published
2002
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6. Expression and role of heat-shock protein 65 (HSP65) in macrophages during Trypanosoma cruzi infection: involvement of HSP65 in prevention of apoptosis of macrophages

Author

Sakai, Tohru, primary, Hisaeda, Hajime, additional, Ishikawa, Hiroyuki, additional, Maekawa, Yoichi, additional, Zhang, Manxin, additional, Nakao, Yoko, additional, Takeuchi, Tsutomu, additional, Matsumoto, Kozo, additional, Good, Robert A, additional, and Himeno, Kunisuke, additional

Published
1999
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7. Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.

Author

Onishi K, Li Y, Ishii K, Hisaeda H, Tang L, Duan X, Dainichi T, Maekawa Y, Katunuma N, and Himeno K

Subjects
Animals, Antigens, Protozoan metabolism, Cathepsin B antagonists & inhibitors, Cathepsin B metabolism, Cathepsin L, Cathepsins antagonists & inhibitors, Cells, Cultured, Cysteine Endopeptidases, Dipeptides pharmacology, Disease Models, Animal, Epoxy Compounds pharmacology, Immunoglobulin E blood, Immunoglobulin G blood, Interferon-gamma analysis, Interleukin-4 analysis, Leishmaniasis, Cutaneous enzymology, Mice, Mice, Inbred BALB C, Mice, Inbred DBA, Protease Inhibitors pharmacology, Pyridines pharmacology, Th1 Cells metabolism, Th2 Cells immunology, Th2 Cells metabolism, Antigen Presentation, Cathepsins metabolism, Leishmania major immunology, Leishmaniasis, Cutaneous immunology, Th1 Cells immunology
Abstract

Prior to the activation of CD4+ T cells, exogenous proteins are digested by endo/lysosomal enzymes in antigen-presenting cells (APCs) to produce antigenic peptides that are presented on MHC class II molecules. In the studies described here, the functional significance of cathepsin L for antigen processing and Th1/Th2 differentiation in experimental leishmaniasis was investigated. We first demonstrated that cathepsin L is one of the candidates for endo/lysosomal enzymes in the processing of soluble Leishmania antigen (SLA) by using CLIK148, a specific inhibitor of cathepsin L. Treatment of BALB/c or DBA/2 mice with CLIK148 exacerbated the disease by enhancing an SLA-specific Th2-type response such as IL-4 production. CLIK148 did not exert any direct influence on Leishmania major promastigotes themselves or on the course of L. major infection in SCID mice. Taken together, these findings suggest that treatment of host mice with CLIK148 affects the processing of SLA in APCs, resulting in the potentiation of Th2-type immune responses and thus leading to exacerbation of the disease. Furthermore, endo/lysosomal cathepsin L was found to be functionally distinct from previously described cathepsins B and D.

Published
2004
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