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2 results on '"Jacques Kaboré"'

1. Trypanosome-induced Interferon-γ production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections

Author

Roukiyath Amoussa, Bruno Bucheton, Vincent Jamonneau, Hamidou Ilboudo, Mathurin Koffi, Jacques Kaboré, Philippe Holzmuller, André Garcia, David Courtin, Unité de Recherches sur les Bases Biologiques de la Lutte Intégrée, Centre International de Recherche Développement sur l'Elevage en Zone Subhumide (CIRDES), Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides (UMR INTERTRYP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bordeaux (UB), Université Jean Lorougnon Guédé (UJloG ), Université Polytechnique de Bobo Dioulasso, Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et l’Enfance (CERPAGE), University of Abomey Calavi (UAC), Contrôle des maladies animales exotiques et émergentes (UMR CMAEE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Programme National de Lutte contre la Trypanosomiase Humaine Africaine, République Démocratique du Congo, Institut de Recherche pour le Développement (IRD), and Université Sorbonne Paris Cité (COMUE) (USPC)

Subjects
0301 basic medicine, Trypanosoma brucei gambiense, medicine.medical_treatment, Sang, L73 - Maladies des animaux, Interferon, Immunologie, Infection control, African trypanosomiasis, Interferon gamma, Trypanosoma brucei, biology, Contrôle de maladies, 000 - Autres thèmes, 3. Good health, Infectious Diseases, Cytokine, Tolérance, whole blood stimulation, L72 - Organismes nuisibles des animaux, medicine.drug, trypanotolerance, Whole blood stimulation, Immunology, Microbiology, IFN-gamma, Interferon-gamma, 03 medical and health sciences, Maladie de l'homme, Immune system, parasitic diseases, medicine, Humans, Diagnostic, Réponse immunitaire, biology.organism_classification, medicine.disease, Virology, cytokines, Trypanosomiasis, African, 030104 developmental biology, human african trypanosomiasis, Leukocytes, Mononuclear, Interféron, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

International audience; Control of human African trypanosomiasis (HAT) is highly dependent on the ability to detect and treat infected individuals. However, a number of individuals exposed to Trypanosoma brucei gambiense are able to control infection to undetectable levels in blood. They are long-term potential reservoirs and thus a threat for control strategies. Cytokine responses in whole blood stimulation assays were quantified in individuals with contrasting HAT status. Trypanosome-induced IFN-gamma production was only observed in "trypanotolerant" subjects suspected of harboring latent infections. This result contributes new insights into the immune responses associated with infection control and opens novel diagnosis perspectives regarding HAT elimination.

Published
2016
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2. Diversity of response to Trypanosoma brucei gambiense infections in the Forecariah mangrove focus (Guinea): perspectives for a better control of sleeping sickness

Author

Oumou Camara, Hassane Sakande, Fabrice Courtin, Vincent Jamonneau, Abdoulaye Diarra, Mamadou Leno, René Sanon, Eliézer K. N’Goran, Bruno Bucheton, Bamoro Coulibaly, Mamadou Camara, Frédéric Ouendeno, Jacques Kaboré, Emilie Dama, Hamidou Ilboudo, and Louis N’Dri

Subjects
Adult, Male, Veterinary medicine, Adolescent, Epidemiology, Trypanosoma brucei gambiense, Immunology, Population, Prevalence, Context (language use), Biology, Polymerase Chain Reaction, Microbiology, Control strategy, Serology, Young Adult, parasitic diseases, Host response, medicine, Humans, African trypanosomiasis, Trypanosoma brucei, Child, education, Mass screening, Aged, Aged, 80 and over, Immunoassay, education.field_of_study, Clinical Laboratory Techniques, Human African trypanosomiasis, Infant, Newborn, Infant, virus diseases, Middle Aged, gambiense, medicine.disease, Virology, Trypanosomiasis, African, Infectious Diseases, Child, Preschool, Carrier State, Female, Guinea, Asymptomatic carrier, Trypanosomiasis, Follow-Up Studies
Abstract

At a time when human African trypanosomiasis (HAT) elimination again seems a reachable goal in many parts of sub-Saharan Africa, it is becoming increasingly important to characterise the factors involved in disease resurgence or maintenance to develop sustainable control strategies. In this study conducted in the Forecariah mangrove focus in Guinea, HAT patients and serological suspects (SERO) were identified through mass screening of the population with the Card Agglutination Test for Trypanosomiasis (CATT) and were followed up for up to 2 years. Analysis of the samples collected during the follow-up of HAT patients and SERO was performed with PCR (TBR1/TBR2) and the trypanolysis serological test (TL) in order to clarify the role played by these individuals in the epidemiology of HAT. PCR positivity was higher in TL + than in SERO TL − (50% vs. 18%, respectively). Whereas CATT plasma titres decreased both in treated HAT patients and SERO TL − , SERO TL + maintained high CATT titres. Four out of 17 SERO TL + developed HAT during the study. These results strongly suggest that SERO TL + individuals are asymptomatic carriers. In the context where disease prevalence is sufficiently low, treating SERO TL + individual may thus be of crucial importance in order to cut transmission.

Published
2011
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