Search

Your search keyword '"MESH: Antigens, Bacterial"' showing total 2 results
Start Over Descriptor "MESH: Antigens, Bacterial" Journal microbes and infection
2 results on '"MESH: Antigens, Bacterial"'

1. Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response

Author

Mauricio Rojas, Jérôme Nigou, Luis F. García, Martine Gilleron, Germain Puzo, Martin Thurnher, Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
Lipopolysaccharides, MESH: Signal Transduction, MESH: Mycobacterium tuberculosis, medicine.medical_treatment, Immunology, Apoptosis, Receptors, Cell Surface, Microbiology, Mycobacterium tuberculosis, 03 medical and health sciences, medicine, Humans, Tuberculosis, Macrophage, MESH: Tuberculosis, MESH: Receptors, Cell Surface, 030304 developmental biology, Antigens, Bacterial, MESH: Cytokines, 0303 health sciences, MESH: Humans, Innate immune system, Lipoarabinomannan, Lipomannan, MESH: Dendritic Cells, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], biology, 030306 microbiology, Macrophages, MESH: Apoptosis, MESH: Macrophages, Dendritic Cells, Dendritic cell, bacterial infections and mycoses, biology.organism_classification, 3. Good health, carbohydrates (lipids), Infectious Diseases, Cytokine, Interleukin 12, Cytokines, MESH: Lipopolysaccharides, MESH: Antigens, Bacterial, Signal Transduction
Abstract

International audience; The molecular bases of Mycobacterium tuberculosis pathogenicity remain unclear. We report here how M. tuberculosis mannosylated lipoarabinomannans contribute to the survival of bacilli in the human reservoir by (i) inhibiting IL-12 production by macrophages and dendritic cells and (ii) modulating M. tuberculosis-induced macrophage apoptosis.

Published
2002
Full Text
View/download PDF

2. Towards an immunodiagnostic test for leprosy

Author

Yakouba Cissoko, Marc Monot, Samba O. Sow, Stewart T. Cole, Charles Arama, Patrick J. Brennan, Romulo Aráoz, Caroline Demangel, S. K. Abdul Hadi, Sang Nae Cho, Nadine Honoré, Sayera Banu, Mohammad Khaja Mafij Uddin, Baohong Ji, Génétique Moléculaire Bactérienne, Institut Pasteur [Paris] (IP), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Department of Epidemiology of Parasitic Diseases, Université de Bamako-Malaria Research and Training Centre, Leprosy Control Institute & Hospital, Hospital Dakka, Yonsei University College of Medicine, Association Française Raoul Follereau [France], Department of Microbiology, Immunology and Pathology, Colorado State University [Fort Collins] (CSU), Centre National d'Appui à la lutte Contre la Maladie [Mali], This work was supported by the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR grant number A20527), the Association Française Raoul Follereau, and the National Institutes of Health, National Institute of Allergy and Infectious Diseases (grants no. 1 RO1-AI47197-01A1, NO1-AI25469)., and Institut Pasteur [Paris]

Subjects
medicine.medical_treatment, T-Lymphocytes, MESH: Amino Acid Sequence, Mice, 0302 clinical medicine, MESH: Antibodies, Bacterial, Interferon gamma, MESH: Animals, Mycobacterium leprae, Cells, Cultured, 0303 health sciences, biology, MESH: Peptides, MESH: Enzyme-Linked Immunosorbent Assay, Antibodies, Bacterial, 3. Good health, MESH: Leukocytes, Mononuclear, Infectious Diseases, Cytokine, MESH: Immunologic Tests, Female, Leprosy, Comparative proteomics, medicine.drug, MESH: Cells, Cultured, Antigenicity, Tuberculosis, MESH: Interferon-gamma, 030231 tropical medicine, Immunology, Molecular Sequence Data, Enzyme-Linked Immunosorbent Assay, Immunologic Tests, Microbiology, 03 medical and health sciences, IFN-g, Interferon-gamma, Immune system, Antigen, MESH: Mice, Inbred C57BL, medicine, Animals, Humans, Amino Acid Sequence, MESH: Mice, 030304 developmental biology, Antigens, Bacterial, MESH: Humans, MESH: Molecular Sequence Data, Comparative genomics, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, medicine.disease, biology.organism_classification, Virology, Phenolic glycolipid-1, MESH: Leprosy, Mice, Inbred C57BL, MESH: T-Lymphocytes, Leukocytes, Mononuclear, MESH: Mycobacterium leprae, Peptides, MESH: Female, MESH: Antigens, Bacterial, Leprosy immunodiagnosis
Abstract

International audience; In addition to multidrug therapy, elimination of leprosy requires improved diagnostic methods. Using a comparative genomics approach, 17 potential protein antigens (MLP) that are restricted to Mycobacterium leprae, or of limited distribution, were produced and tested for antigen-specific immune responses on leprosy patients, healthy contacts of leprosy patients, and tuberculosis patients in Mali and Bangladesh, as well as on non-endemic controls. T-cell antigenicity of MLP was confirmed by IFN-gamma production in whole-blood assays with the highest responses observed in paucibacillary leprosy patients and healthy contacts. Four MLP behaved well in both countries and induced significantly different responses between the study groups. Peptides carrying T cell epitopes from one of the antigens gave promising results in restimulation assays in mice and immune responses were not influenced by prior exposure to BCG or environmental mycobacteria. This study provides the immunological framework for the development of a specific, peptide-based immunodiagnostic test for leprosy.

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results