1. Single Red Blood Cell Hydrodynamic Traps via the Generative Design
- Author
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Georgii V. Grigorev, Nikolay O. Nikitin, Alexander Hvatov, Anna V. Kalyuzhnaya, Alexander V. Lebedev, Xiaohao Wang, Xiang Qian, Georgii V. Maksimov, and Liwei Lin
- Subjects
microfluidics ,cell trap ,RBC ,evolutionary algorithm ,generative design ,artificial intelligence ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
This paper describes a generative design methodology for a micro hydrodynamic single-RBC (red blood cell) trap for applications in microfluidics-based single-cell analysis. One key challenge in single-cell microfluidic traps is to achieve desired through-slit flowrates to trap cells under implicit constraints. In this work, the cell-trapping design with validation from experimental data has been developed by the generative design methodology with an evolutionary algorithm. L-shaped trapping slits have been generated iteratively for the optimal geometries to trap living-cells suspended in flow channels. Without using the generative design, the slits have low flow velocities incapable of trapping single cells. After a search with 30,000 solutions, the optimized geometry was found to increase the through-slit velocities by 49%. Fabricated and experimentally tested prototypes have achieved 4 out of 4 trapping efficiency of RBCs. This evolutionary algorithm and trapping design can be applied to cells of various sizes.
- Published
- 2022
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