1. A Mouse Model for Studying Post-Acute Arthritis of Chikungunya
- Author
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Aileen Y. Chang, Sarah R. Tritsch, Abigail J. Porzucek, Arnold M. Schwartz, Margaux Seyler-Schmidt, Arielle Glass, Patricia S. Latham, St. Patrick Reid, Gary L. Simon, and Christopher N. Mores
- Subjects
chikungunya ,mouse model ,arthritis ,arthritis therapy ,myositis ,bone erosion ,Biology (General) ,QH301-705.5 - Abstract
Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are lacking. Multiple mouse models of chikungunya have been developed to study acute CHIKV infection. In humans, post-CHIKV arthritis may persist for months to years after viremia from a CHIKV infection has resolved. Therefore, the development of a mouse model of post-acute arthritis of chikungunya may facilitate the study of potential novel therapeutics for this arthritis. In this article we describe the development of a wild-type immunocompetent C57BL/6 mouse model for post-acute arthritis of chikungunya, including a histologic inflammation scoring system, as well as suggestions for how this mouse model may be used to examine the efficacy of novel therapies for CHIKV arthritis.
- Published
- 2021
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