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The surrounding rock control technology of mining roadways in large inclination seams with a weak structural plane in the roof is one of the most challenging fields in underground roadway support. In view of the serious deformation of the surrounding rock of the transportation roadway in the 1201 working face of a mine, the deformation and failure characteristics and instability mechanism of the surrounding rock of the roadway are analysed. The self-stability mechanical model of the roof block structure of the roadway with a large inclination under the support effect is established, and the support concept of "high pre-stressed asymmetric" and the combined support method of bolts, wire mesh, and cables are proposed. The rationality of the supporting scheme is verified by numerical simulation. The results show that: compared with bolt and wire mesh support, the maximum shear displacement of the roof's weak layer under the combined support of bolt, wire meshes, and cable before and after mining is reduced by 86.78% and 83%, respectively, and the maximum total displacement of surrounding rock surface is reduced by 49.22% and 37.1%, respectively. The field monitoring results show that the combined support scheme can effectively control the deformation of the surrounding rock. [ABSTRACT FROM AUTHOR]