1. [Multicenter study of the effectiveness and tolerance of clotiazepam in cardiology].
- Author
-
Colonna L, Cozzi F, Del Citerna F, Di Benedetto A, De Divitiis O, Furlanello F, Milazzotto F, Pittalis M, and Taccola A
- Subjects
- Adolescent, Adult, Aged, Anxiety complications, Azepines administration & dosage, Drug Evaluation, Female, Humans, Male, Middle Aged, Multicenter Studies as Topic, Psychiatric Status Rating Scales, Anxiety drug therapy, Azepines therapeutic use, Cardiovascular Diseases psychology
- Abstract
In a phase IV study with clotiazepam 9 cardiologists were involved to treat 86 patients (52 female, 32 male, mean age 51 years) effected by cardiovascular diseases and anxiety. The dosage was 5-10 mg TID, and the treatment lasted for 3 weeks. Variations of the dosage were requested in 21% of patients and generally at the 2nd week of treatment. The safety of clotiazepam was good: only in the 14% of patients side-effects were observed (especially drowsiness 9.3% and asthenia 2.3%). Clotiazepam was judged to be effective in 75% of patients. The Hamilton psychiatric rating scale for anxiety showed a progressive decrease both of the total score and of the scores of every item; the cardiovascular symptoms particularly improved at both the controls.
- Published
- 1990