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In this paper, we introduce a new function class called n-fractional polynomial convex function and their some algebric properties. We obtain some refinements of the right-hand side of Hermite-Hadamard inequality for the class of functions whose derivatives in absolutely value at certain powers are n-fractional polynomial convex. Also, we compare the results obtained with both Hölder, Hölder-İşcan inequalities and power-mean, improved-power-mean integral inequalities and show that the result obtained with Hölder-İşcan and improved power-mean inequalities give better approach than the others. Some applications to special means of real numbers are also given. [ABSTRACT FROM AUTHOR]