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The effect of the iodine not bound to the nuclear drug 131I hippurate on nuclear medical renal diagnosis by means of whole body clearance has been investigated. The results show that whatever clearance method is used, the tubular secretion performance decreases with increasing free iodine. This results in considerable error if the free iodine in the nuclear drug is not taken into account in the clearance calculation.

The formation of urinary calculi cannot yet be prevented with certainty. Consequently the dissolution of stones remains a focus of medical interest. The speed of solution of a calculus is not a quantity typical of the substance, but depends largely on the structural formation of the urinary calculi. With very different types of structure (e.g. Whewellite and Weddellite stones) the rate of dissolution can therefore fluctuate between wide limits in spite of similar phase composition. Consequently, type of structure, course of solution and rate of solution can be clearly correlated. Stones with relatively uniform structure formation (e.g. Struvite stones) on the other hand show largely similar solution rates. Medically, it is of interest that in certain structural types, solution may lead to disintegration of the stone into isolated solution residues.