1. Serum ferritin correlates with activity of anti-MDA5 antibody-associated acute interstitial lung disease as a complication of dermatomyositis
- Author
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Takashi Satoh, Takahisa Gono, Masako Hara, Yuko Ota, Yasushi Kawaguchi, Masataka Kuwana, Eri Ozeki, and Hisashi Yamanaka
- Subjects
Adult ,medicine.medical_specialty ,Interferon-Induced Helicase, IFIH1 ,Gastroenterology ,Dermatomyositis ,DEAD-box RNA Helicases ,Rheumatology ,Internal medicine ,medicine ,Humans ,Aged ,biology ,business.industry ,Interstitial lung disease ,MDA5 ,medicine.disease ,Ferritin ,Immunology ,Acute Interstitial Pneumonia ,Acute Disease ,Ferritins ,biology.protein ,Female ,Antibody ,Drug Monitoring ,Complication ,business ,Lung Diseases, Interstitial ,Immunosuppressive Agents - Abstract
Dermatomyositis (DM) is occasionally complicated by interstitial lung disease. Acute/subacute interstitial pneumonia (A/SIP) with DM is intractable and life threatening. Clinically amyopathic dermatomyositis (C-ADM) is also reported to be complicated with A/SIP, especially in those patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody. In the present cases, we indicate that serum ferritin level correlated with activity of A/SIP with DM. Two patients, a 65-year-old woman and a 30-year-old woman, were diagnosed with anti-MDA5 antibody-associated A/SIP with DM. Serum ferritin was high, 1600 and 770 mg/dl, respectively, on admission. Immunosuppressive therapy ameliorated A/SIP in both cases. Similarly, serum ferritin was also decreasing. However, A/SIP was recurrent and progressive, and serum ferritin was also increasing again in one case. In conclusion, serum ferritin correlates with disease activity of anti-MDA5 antibody-associated A/SIP with DM. Intensity of treatment may be decided according to serum ferritin level.
- Published
- 2011