Search

The title compound, 4,4-bis(hydroxymethyl)-2-phenyl-2-oxazoline 2, a well-known substance, was resynthesized in high yields through a conventional method. The structure of compound 2 was characterized for the first time by a single-crystal X-ray structure determination. The compound was further established through NMR spectroscopy (1D and 2D). In the molecular packing, two molecules of 4,4-bis(hydroxymethyl)-2-phenyl-2-oxazoline interact through H-Bonds to define “dimers” in which phenyl groups interact especially using π…π contact.

The product 2 was prepared by the addition of piperazine (C4H10N2) to 1 [1] according to the reported procedure [2].[...]

)-one, N-alkylation, anticonvulsive agents. Pyridazines are of chemical and biological interest. They have been reported to be anticonvulsive agents[1], [2]. Furthermore, BELLASIO et al. have described the antihypertensive effects ofhydrazinopyridazine compounds [3]. In continuation of this line of investigation, we have synthesizedcompound (I); it will be subjected to further pharmacological investigations, especially tests of itsanticancer activity. To ( 0.96 g, 3 mmol) of ethyl [4-(2-chlorobenzyl)-3-methyl-6-oxopyridazin-1(6H)-yl)] acetate (I), wasadded 10 ml of hydrazine hydrate. The mixture was placed in a pyrex tube which was then introduced intoa Maxidigest MX 350 Prolabo microwave[4] monomode reactor and refluxed for 10 min on 60 w asirradiation power. After cooling, the product precipitates, and then is recristallised in absolute ethanol,yield : 80 % of (II) solid. Melting point: 201-205°C IR (KBr, cm

)-one, N-alkylation, anticonvulsive agents. Pyridazines are of chemical and biological interest. They have been reported to be anticonvulsive agents[1], Furthermore, Gehrlein et al. have described the antihypertensive effects of novelhydroxyethylpyridazine compounds [2]. In continuation of this line of investigation, we have synthesizedcompound (I); it will be subjected to further pharmacological investigations, especially tests of itsanticancer activity. The product (II) was prepared from 5-(2-chlorobenzyl)-6-methylpyridazin-3(2H)-one (I) in situ by thesolid-liquid PTC conditions without solvent [3]. To pyridazin (I) (1.4 g, 6 mmol) was added (2.75 g, 9mmol) of potassium carbonate, (0.3 g, 1 mmol) of TBAB and (1 g, 6 mmol) of 2-ethyl bromoacetate. Themixture was placed in a pyrex tube which was then introduced into a Maxidigest MX 350 Prolabomicrowave monomode reactor fitted with a rotational system. At the end of the irradiation time (10 min on90 w as irradiation power), the mixture was cooled to ambient temperature. After elution with ethyl acetate(30 ml) and subsequent filtration on florisil, the organic product was purified by chromatography on silicagel using CH