1. APOBEC3 as a driver of genetic intratumor heterogeneity
- Author
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Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F. Bakhoum, Jiri Bartek, Nnennaya Kanu, and Charles Swanton
- Subjects
apobec ,non-small cell lung cancer ,breast cancer ,intratumor heterogeneity ,chromosomal instability ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.
- Published
- 2021
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