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Your search keyword '"Carrington, Mark"' showing total 25 results
Start Over Author "Carrington, Mark" Journal molecular and biochemical parasitology
25 results on '"Carrington, Mark"'

8. The four trypanosomatid eIF4E homologues fall into two separate groups, with distinct features in primary sequence and biological properties

Author

Freire, Eden R., primary, Dhalia, Rafael, additional, Moura, Danielle M.N., additional, da Costa Lima, Tamara D., additional, Lima, Rodrigo P., additional, Reis, Christian R.S., additional, Hughes, Katie, additional, Figueiredo, Regina C.B.Q., additional, Standart, Nancy, additional, Carrington, Mark, additional, and de Melo Neto, Osvaldo P., additional

Published
2011
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13. The coatomer of Trypanosoma brucei

Author

Maier, Alexander G, primary, Webb, Helena, additional, Ding, Martina, additional, Bremser, Martina, additional, Carrington, Mark, additional, and Clayton, Christine, additional

Published
2001
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15. Conservation of genetic linkage between heat shock protein 100 and glycosylphosphatidylinositol-specific phospholipase C in Trypanosoma brucei and Trypanosoma cruzi1Note: Nucleotide sequence data reported in this paper are available in the EMBL, GenBank and DDJB databases under the accession numbers: AJ 000080, Trypanosoma brucei hsp100 and gpi-plc AJ000079, Trypanosoma cruzi plc1.1

Author

Redpath, Maria B, primary, Carnall, Nicola, additional, Webb, Helena, additional, Courel, Maria, additional, Amorim, Antonio, additional, Güther, Maria Lucia S, additional, Cardoso de Almeida, Maria Lucia, additional, and Carrington, Mark, additional

Published
1998
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25. VSG mRNA levels are regulated by the production of functional VSG protein

Author

Steve Kelly, Angela Schwede, Mark Carrington, Isabella E. Maudlin, Carrington, Mark [0000-0002-6435-7266], and Apollo - University of Cambridge Repository

Subjects
Transgene, Trypanosoma brucei brucei, 030231 tropical medicine, Population, Biology, Trypanosoma brucei, Article, Cell Line, Host-Parasite Interactions, 03 medical and health sciences, 0302 clinical medicine, parasitic diseases, Antigenic variation, RNA, Messenger, education, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Messenger RNA, education.field_of_study, biology.organism_classification, VSG mRNA, Cell biology, Trypanosomiasis, African, Gene Expression Regulation, chemistry, Parasitology, Ectopic expression, Glycoprotein, Variant Surface Glycoproteins, Trypanosoma, Cytokinesis
Abstract

Highlights • VSG mRNA copy number varies with the identity of the VSG. • Early premature termination codons result in degradation of VSG mRNA. • Late premature termination codons translated to produce incomplete VSG result in an increase in VSG mRNA. • There is a feedback pathway between non-functional VSG production and VSG mRNA levels., The bloodstream form of Trypanosoma brucei persists in mammalian hosts through a population survival strategy depending on antigenic variation of a cell surface coat composed of the variant surface glycoprotein (VSG). The integrity of the VSG coat is essential and blocking its synthesis results in a cell division cycle arrest just prior to cytokinesis. This observation indicates that VSG levels are monitored and that the cell has mechanisms to respond to a disruption of synthesis. Here, the regulation of VSG mRNA levels has been investigated by first measuring VSG mRNA copy number, and second using ectopic expression of VSG transgenes containing premature termination codons. The findings are that (i) VSG mRNA copy number varies with the identity of the VSG and (ii) a pathway detects synthesis of non-functional VSG protein and results in an increase in VSG mRNA levels.

Published
2021

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