1. 7TM proteins are not necessarily GPCRs
- Author
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Ieva Vasiliauskaité-Brooks, Robert D. Healey, Sébastien Granier, Institut de Génomique Fonctionnelle (IGF), and Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
0301 basic medicine ,[SDV]Life Sciences [q-bio] ,Hydrolase activity ,Sequence Homology ,030209 endocrinology & metabolism ,Computational biology ,Biology ,Biochemistry ,Amidohydrolases ,Receptors, G-Protein-Coupled ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Hydrolase ,medicine ,Animals ,Humans ,Amino Acid Sequence ,Receptor ,Molecular Biology ,G protein-coupled receptor ,Membrane Proteins ,Transmembrane protein ,Review article ,030104 developmental biology ,Mechanism of action ,Structural biology ,Receptors, Adiponectin ,medicine.symptom - Abstract
International audience; In this review article, we summarize the current knowledge on a large and diverse superfamily of seven-pass transmembrane proteins functionally independent from the GPCR superfamily. We include the newest research findings about their physiological roles and their mechanism of action. In particular, we concentrate on the structural basis for the newly discovered amide hydrolase activity, with a focus on adiponectin receptors for which structures are available. Finally, we discuss the remaining challenges in understanding the activation and signaling of these intramembrane proteins and suggest how regulation of the amide hydrolase activity may help in development of new therapeutic agents.
- Published
- 2019
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