1. A novel role for the Receptor for Advanced Glycation End-products in neural progenitor cells derived from adult SubVentricular Zone.
- Author
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Meneghini V, Francese MT, Carraro L, and Grilli M
- Subjects
- Animals, Cell Differentiation drug effects, Glycation End Products, Advanced pharmacology, Male, Mice, NF-kappa B metabolism, Neural Stem Cells drug effects, Neurogenesis drug effects, Receptor for Advanced Glycation End Products, Up-Regulation, Cerebral Ventricles cytology, Glycation End Products, Advanced metabolism, Nerve Tissue Proteins metabolism, Neural Stem Cells physiology, Receptors, Immunologic metabolism
- Abstract
The Receptor for Advanced Glycation End-products (RAGE) is a member of the immunoglobulin superfamily of cell surface receptors which interacts with a wide range of ligands, such as High-Mobility Group Box-1 (HMGB-1), S100B, advanced glycation end-products (AGEs). Here we provided evidence for the restricted expression of RAGE in the undifferentiated neural stem/progenitor cells of mouse adult SubVentricular Zone (SVZ) neurogenic region and adult SVZ-derived neurospheres. Additionally, RAGE ligands stimulated both proliferation and neuronal differentiation of SVZ-derived neural progenitor cells (NPC) in vitro. NF-kappaB nuclear translocation occurred upon RAGE activation in SVZ-derived neurospheres and its blockade (by SN-50) or its absence (in p50(-/-) derived NPC) resulted in the inhibition of the ligand-mediated effects on neuronal differentiation. These novel findings delineate an interesting scenario where the RAGE-NF-kappaB axis may contribute to regulate adult neural stem/progenitor cell function in physiological and possibly pathological conditions where this axis is upregulated., (Copyright 2010 Elsevier Inc. All rights reserved.)
- Published
- 2010
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