Author: "Zent, Roy" / Journal: molecular biology of the cell - Searchworks@Jio Institute Digital Library Search Results

Author: Starchenko, Alina, primary, Graves-Deal, Ramona, additional, Yang, Yu-Ping, additional, Li, Cunxi, additional, Zent, Roy, additional, Singh, Bhuminder, additional, and Coffey, Robert J., additional
Published: 2017
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Author: Yazlovitskaya, Eugenia M., primary, Tseng, Hui-Yuan, additional, Viquez, Olga, additional, Tu, Tianxiang, additional, Mernaugh, Glenda, additional, McKee, Karen K., additional, Riggins, Karen, additional, Quaranta, Vito, additional, Pathak, Amrita, additional, Carter, Bruce D., additional, Yurchenco, Peter, additional, Sonnenberg, Arnoud, additional, Böttcher, Ralph T., additional, Pozzi, Ambra, additional, and Zent, Roy, additional
Published: 2015
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Author: Cleghorn, Whitney M., primary, Branch, Kevin M., additional, Kook, Seunghyi, additional, Arnette, Christopher, additional, Bulus, Nada, additional, Zent, Roy, additional, Kaverina, Irina, additional, Gurevich, Eugenia V., additional, Weaver, Alissa M., additional, and Gurevich, Vsevolod V., additional
Published: 2015
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Author: Miller, Charles G., primary, Pozzi, Ambra, additional, Zent, Roy, additional, and Schwarzbauer, Jean E., additional
Published: 2014
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Author: Zeng, Fenghua, primary, Zhang, Ming-Zhi, additional, Singh, Amar B., additional, Zent, Roy, additional, and Harris, Raymond C., additional
Published: 2007
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Author: Pozzi, Ambra, primary, Coffa, Sergio, additional, Bulus, Nada, additional, Zhu, Wenqin, additional, Chen, Dong, additional, Chen, Xiwu, additional, Mernaugh, Glenda, additional, Su, Yan, additional, Cai, Songmin, additional, Singh, Amar, additional, Brissova, Marcela, additional, and Zent, Roy, additional
Published: 2006
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Author: Mai, Weiyi, primary, Chen, Dong, additional, Ding, Tianbing, additional, Kim, Ingyu, additional, Park, Sujun, additional, Cho, Sae-youll, additional, Chu, Julia S.F., additional, Liang, Dan, additional, Wang, Ning, additional, Wu, Dianqing, additional, Li, Song, additional, Zhao, Ping, additional, Zent, Roy, additional, and Wu, Guanqing, additional
Published: 2005
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Author: Mai, Weiyi, Chen, Dong, Ding, Tianbing, Kim, Ingyu, Park, Sujun, Cho, Sae-youll, Chu, Julia S.F., Liang, Dan, Wang, Ning, Wu, Dianqing, Li, Song, Zhao, Ping, Zent, Roy, and Wu, Guanqing
Abstract: Fibrocystin/polyductin (FPC), the gene product of PKHD1, is responsible for autosomal recessive polycystic kidney disease (ARPKD). This disease is characterized by symmetrically large kidneys with ectasia of collecting ducts. In the kidney, FPC predominantly localizes to the apical domain of tubule cells, where it associates with the basal bodies/primary cilia; however, the functional role of this protein is still unknown. In this study, we established stable IMCD (mouse inner medullary collecting duct) cell lines, in which FPC was silenced by short hairpin RNA inhibition (shRNA). We showed that inhibition of FPC disrupted tubulomorphogenesis of IMCD cells grown in three-dimensional cultures. Pkhd1-silenced cells developed abnormalities in cell-cell contact, actin cytoskeleton organization, cell-ECM interactions, cell proliferation, and apoptosis, which may be mediated by dysregulation of extracellular-regulated kinase (ERK) and focal adhesion kinase (FAK) signaling. These alterations in cell function in vitro may explain the characteristics of ARPKD phenotypes in vivo.
Published: 2005
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