1. Cervical cancer and potential pharmacological treatment with snake venoms
- Author
-
Leonel Montealegre-Sánchez, Eliécer Jiménez-Charris, Herney Andrés García-Perdomo, and Alejandro Montoya-Gómez
- Subjects
0301 basic medicine ,Angiogenesis ,Uterine Cervical Neoplasms ,Apoptosis ,Venom ,Viper Venoms ,03 medical and health sciences ,0302 clinical medicine ,Cell Movement ,Viperidae ,biology.animal ,Tumor Microenvironment ,Genetics ,medicine ,Animals ,Humans ,Cytotoxicity ,Molecular Biology ,Toxins, Biological ,Cervical cancer ,Tumor microenvironment ,Neovascularization, Pathologic ,biology ,business.industry ,Cancer ,General Medicine ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Female ,business ,Snake Venoms - Abstract
Cervical cancer is the fourth most common cancer worldwide in women. Apoptosis reactivation has become the main strategy for decreasing cancer proliferation. There is a need to extend the search for new drugs to implement more effective and less toxic strategies for cervical cancer treatment. Research has been carried out to find new drugs that have minimal side effects and that focus on the tumor microenvironment, particularly in the induction of cellular apoptosis and cell migration and the inhibition of angiogenesis. Potent toxins from snake venoms have shown potential as sources for the synthesis of new drugs with such characteristics. The present work aimed to describe cervical cancer characteristics, associated risk factors, current treatments and to highlight the effects of toxins isolated from the venom of snakes of the Viperidae family on cervical cancer cell lines.
- Published
- 2020
- Full Text
- View/download PDF